Evidence map›Paper›PMID 31064617›Full record

ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2019

Treatment as prevention and other interventions to reduce transmission of multidrug-resistant tuberculosis.

R R Nathavitharana, P Lederer, D B Tierney, E Nardell

Open access · greenAbstract read
In one paragraph

Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

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  12. New Developments and Insights in the Improvement ofCurrent epidemiology reports · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

R R NathavitharanaDivision of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
P LedererSection of Infectious Diseases, Boston Medical Center, Boston, Massachusetts.
D B TierneyDivision of Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts, USA.
E NardellDivision of Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Brigham and Women's Hospital · USBeth Israel Deaconess Medical Center · USBoston Medical Center · US

Funding

INFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMST32AI007061 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Marcia B Goldberg · 1985 to 2026
$12.1M
Finding and Treating Unsuspected and Resistant TB to Reduce Hospital TransmissionR01AI112748 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI NARDELL, EDWARD A., TIERNEY, DYLAN · 2015 to 2019
$3.5M
Innovative Interdisciplinary Approaches to Sustainable Airborne Infection ControlD43TW009379 · FIC · BRIGHAM AND WOMEN'S HOSPITAL · PI NARDELL, EDWARD A. · 2012 to 2016
$1.9M
Optimizing Diagnostic Strategies for TB Transmission Control in Health-Care FacilitiesK23AI132648 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI NATHAVITHARANA, RUVANDHI · 2018 to 2022
$945k
FIC NIH HHS D43 TW009379NIAID NIH HHS K23 AI132648NIAID NIH HHS R01 AI112748NIAID NIH HHS T32 AI007061
6 · The paper itself

Abstract

Drug-resistant tuberculosis (DR-TB) represents a major programmatic challenge at the national and global levels. Only ∼30% of patients with multidrug-resistant TB (MDR-TB) were diagnosed, and ∼25% were initiated on treatment for MDR-TB in 2016. Increasing evidence now points towards primary transmission of DR-TB, rather than inadequate treatment, as the main driver of the DR-TB epidemic. The cornerstone of DR-TB transmission prevention should be earlier diagnosis and prompt initiation of effective treatment for all patients with DR-TB. Despite the extensive scale-up of Xpert

Indexed as

Antitubercular AgentsEarly DiagnosisHumansMolecular Diagnostic TechniquesTuberculosis, Multidrug-ResistantAntitubercular Agents

Identifiers

PMID31064617
PMCPMC6648686
OpenAlexW2943982070

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.