ArticleDevelopment and psychopathology2019
Early life stress, cortisol, frontolimbic connectivity, and depressive symptoms during puberty.
Article in Development and psychopathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Brain-based Sex Differences in Depression: A Systematic Review of Neuroimaging Studies.Brain imaging and behavior · 2023Pooled it
- Substance use involvement moderates the effect of cortisol response on white-matter microstructure longitudinally.Dialogues in clinical neuroscience · 2026Article
- Autonomic and limbic system functioning, early life stress, and depressive symptoms in adolescence.Neurobiology of stress · 2026Article
- The association between psychosocial stress trajectories and emotional and behavioral problems in children and adolescents.European child & adolescent psychiatry · 2026Article
- Women's mental health: current status and evolutionary perspectives.Evolutionary human sciences · 2026Review
- Adolescent Depressive Symptom Trajectories From Before to After the COVID-19 Pandemic.JAMA network open · 2025Article
- Neighborhood air quality, psychobiological reactivity, and mental health across adolescence.Environmental science and pollution research international · 2025Article
- Connectometry reveals differing associations of cortisol and PACAP with dorsal cingulum microstructure in posttraumatic stress.medRxiv : the preprint server for health sciences · 2025Article
- Stress During Lactation: A Hidden Link to Offspring Bone Health.Calcified tissue international · 2025Article
- Stress reactivity moderates the association between early experiences of unpredictability and emotional problems in adolescents.Neurobiology of stress · 2025Article
- Exposure to diesel-related particulate matter, cortisol stress responsivity, and depressive symptoms in adolescents.Psychoneuroendocrinology · 2025Article
- The growing interdisciplinarity of developmental psychopathology: Implications for science and training.Development and psychopathology · 2024Article
- Associations among early life adversity, sleep disturbances, and depressive symptoms in adolescent females and males: a longitudinal investigation.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- Early life stress predicts trajectories of emotional problems and hippocampal volume in adolescence.European child & adolescent psychiatry · 2024Article
- Neighborhood disadvantage and parenting predict longitudinal clustering of uncinate fasciculus microstructural integrity and clinical symptomatology in adolescents.Developmental cognitive neuroscience · 2024Article
- Protocol for teen inflammation glutamate emotion research (TIGER): Toward predictors of treatment response and clinical course in depressed adolescents.Brain, behavior, & immunity - health · 2024Article
- Socioeconomic Disparities in Hypothalamic-Pituitary-Adrenal Axis Regulation and Prefrontal Cortical Structure.Biological psychiatry global open science · 2024Review
- Neighborhood Socioeconomic Disadvantage and White Matter Microstructure of the Arcuate Fasciculus and Uncinate Fasciculus in Adolescents.Biological psychiatry global open science · 2024Article
- Puberty interacts with sleep and brain network organization to predict mental health.Frontiers in human neuroscience · 2024Article
- Corticolimbic connectivity mediates the relationship between pubertal timing and mental health problems.Psychological medicine · 2023Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Early life stress (ELS) is a risk factor for the development of depression in adolescence; the mediating neurobiological mechanisms, however, are unknown. In this study, we examined in early pubertal youth the associations among ELS, cortisol stress responsivity, and white matter microstructure of the uncinate fasciculus and the fornix, two key frontolimbic tracts; we also tested whether and how these variables predicted depressive symptoms in later puberty. A total of 208 participants (117 females; M age = 11.37 years; M Tanner stage = 2.03) provided data across two or more assessment modalities: ELS; salivary cortisol levels during a psychosocial stress task; diffusion magnetic resonance imaging; and depressive symptoms. In early puberty there were significant associations between higher ELS and decreased cortisol production, and between decreased cortisol production and increased fractional anisotropy in the uncinate fasciculus. Further, increased fractional anisotropy in the uncinate fasciculus predicted higher depressive symptoms in later puberty, above and beyond earlier symptoms. In post hoc analyses, we found that sex moderated several additional associations. We discuss these findings within a broader conceptual model linking ELS, emotion dysregulation, and depression across the transition through puberty, and contend that brain circuits implicated in the control of hypothalamic-pituitary-adrenal axis function should be a focus of continued research.
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Registered trials
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