ArticleProceedings. Biological sciences2019
Parasite resource manipulation drives bimodal variation in infection duration.
Article in Proceedings. Biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Shielded by the dead: how killed bacteria shape the dynamics and evolution of innate immunity.bioRxiv : the preprint server for biology · 2026Article
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- Dose-dependent interaction of parasites with tiers of host defense predicts "wormholes" that prolong infection at intermediate inoculum sizes.PLoS computational biology · 2024Article
- Immunological feedback loops generate parasite persistence thresholds that explain variation in infection duration.Proceedings. Biological sciences · 2024Article
- Managing host-parasite interactions in humans and wildlife in times of global change.Parasitology research · 2022Review
- The evolution of powerful yet perilous immune systems.Trends in immunology · 2022Review
- Size-asymmetric competition among snails disrupts production of human-infectious Schistosoma mansoni cercariae.Ecology · 2021Article
- Host-pathogen immune feedbacks can explain widely divergent outcomes from similar infections.Proceedings. Biological sciences · 2021Article
- Supplemented nutrition decreases helminth burden and increases drug efficacy in a natural host-helminth system.Proceedings. Biological sciences · 2021Article
- Transient disease dynamics across ecological scales.Theoretical ecology · 2021Article
- Disentangling the dynamical underpinnings of differences in SARS-CoV-2 pathology using within-host ecological models.PLoS pathogens · 2020Review
- Resource fluctuations inhibit the reproduction and virulence of the human parasiteProceedings. Biological sciences · 2020Article
- Parasite resource manipulation drives bimodal variation in infection duration.Proceedings. Biological sciences · 2019Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over a billion people on earth are infected with helminth parasites and show remarkable variation in parasite burden and chronicity. These parasite distributions are captured well by classic statistics, such as the negative binomial distribution. But the within-host processes underlying this variation are not well understood. In this study, we explain variation in macroparasite infection outcomes on the basis of resource flows within hosts. Resource flows realize the interactions between parasites and host immunity and metabolism. When host metabolism is modulated by parasites, we find a positive feedback of parasites on their own resources. While this positive feedback results in parasites improving their resource availability at high burdens, giving rise to chronic infections, it also results in a threshold biomass required for parasites to establish in the host, giving rise to acute infections when biomass fails to clear the threshold. Our finding of chronic and acute outcomes in bistability contrasts with classic theory, yet is congruent with the variation in helminth burdens observed in human and wildlife populations.
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