ArticleTissue engineering. Part A2020
Regenerative Repair of Volumetric Muscle Loss Injury is Sensitive to Age.
Article in Tissue engineering. Part A, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Cellular signaling within aged skeletal muscle reveals a dysregulated stress-induced remodeling response following volumetric muscle loss in female mice.Physiological reports · 2026Article
- Biomimetic Scaffolds and Extracellular Matrix-Based Strategies for Myofiber Regeneration in Volumetric Muscle Loss.Drug design, development and therapy · 2026Review
- Critical-Size Muscle Defect Regeneration Using an Injectable Cell-Laden Nanofibrous Matrix: An Ex Vivo Mouse Hindlimb Organ Culture Study.International journal of molecular sciences · 2025Article
- In vivo evaluation of decellularized skeletal muscle matrices for skeletal muscle repair: A systematic review.Bioengineering & translational medicine · 2025Review
- Combinational regenerative inductive effect of bio-adhesive hybrid hydrogels conjugated with hiPSC-derived myofibers and its derived EVs for volumetric muscle regeneration.Bioactive materials · 2025Article
- Age-associated functional healing of musculoskeletal trauma through regenerative engineering and rehabilitation.Biomaterials science · 2024Article
- Local IL-10 delivery modulates the immune response and enhances repair of volumetric muscle loss muscle injury.Scientific reports · 2023Article
- Temporal changes in the muscle extracellular matrix due to volumetric muscle loss injury.Connective tissue research · 2022Article
- Epimorphic regeneration of the mouse digit tip is finite.Stem cell research & therapy · 2022Article
- Extracellular vesicle-derived miRNAs improve stem cell-based therapeutic approaches in muscle wasting conditions.Frontiers in immunology · 2022Article
- Mini review: Biomaterials in repair and regeneration of nerve in a volumetric muscle loss.Neuroscience letters · 2021Review
- Advanced Glycation End Products Are Retained in Decellularized Muscle Matrix Derived from Aged Skeletal Muscle.International journal of molecular sciences · 2021Article
- Administration of a selective retinoic acid receptor-γ agonist improves neuromuscular strength in a rodent model of volumetric muscle loss.Journal of experimental orthopaedics · 2021Article
- Review
- The effect of autologous repair and voluntary wheel running on force recovery in a rat model of volumetric muscle loss.Experimental physiology · 2021Article
- Graft alignment impacts the regenerative response of skeletal muscle after volumetric muscle loss in a rat model.Acta biomaterialia · 2020Article
- New Surgical Model for Bone-Muscle Injury Reveals Age and Gender-Related Healing Patterns in the 5 Lipoxygenase (5LO) Knockout Mouse.Frontiers in endocrinology · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
In this study, the influence of age on effectiveness of regenerative repair for the treatment of volumetric muscle loss (VML) injury was explored. Tibialis anterior (TA) VML injuries were repaired in both 3- and 18-month-old animal models (Fischer 344 rat) using allogeneic decellularized skeletal muscle (DSM) scaffolds supplemented with autologous minced muscle (MM) paste. Within the 3-month animal group, TA peak contractile force was significantly improved (79% of normal) in response to DSM+MM repair. However, within the 18-month animal group, muscle force following repair (57% of normal) was not significantly different from unrepaired VML controls (59% of normal). Within the 3-month animal group, repair with DSM+MM generally reduced scarring at the site of VML repair, whereas scarring and a loss of contractile tissue was notable at the site of repair within the 18-month group. Within 3-month animals, expression of myogenic genes (
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