Evidence map›Paper›PMID 31064095›Full record

ArticleMolecules (Basel, Switzerland)2019

4,5-Diaryl 3(

Dmitrii Semenok, Jury Medvedev, Lefki-P Giassafaki, Iason Lavdas, Ioannis S Vizirianakis, Phaedra Eleftheriou, Antonis Gavalas, Anthi Petrou, Athina Geronikaki

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. An efficient synthesis of furan-3(2Royal Society open science · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Dmitrii SemenokSkolkovo Institute of Science and Technology, Skolkovo Innovation Center, 3 Nobel Street, 143026 Moscow, Russia. dmitrii.semenok@skolkovotech.ru.ORCID 0000-0002-1374-9091
Jury MedvedevSaint-Petersburg State University, Institute of Chemistry, Universitetskiy Prospekt, 26, 198504 Petergof, Russia. j2j3@yandex.ru.ORCID 0000-0002-4156-7455
Lefki-P GiassafakiDepartment of Pharmacology, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. lefkigiassafaki@gmail.com.
Iason LavdasDepartment of Pharmacology, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. iasonlavdas@pharma.uth.gr.
Ioannis S VizirianakisDepartment of Pharmacology, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. ivizir@pharm.auth.gr.
Phaedra EleftheriouDepartment of Medical Laboratory Studies, School of Health and Medical Care, Alexander Technological Educational Institute of Thessaloniki, 57400 Thessaloniki, Greece. eleftheriouphaedra@gmail.com.
Antonis GavalasDepartment of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. agavalas@pharm.auth.gr.
Anthi PetrouDepartment of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. anthi.petrou.thessaloniki1@gmail.com.ORCID 0000-0001-8587-2710
Athina GeronikakiDepartment of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. geronik@pharm.auth.gr.
Aristotle University of Thessaloniki · GRAlexander Technological Educational Institute of Thessaloniki · GRSkolkovo Institute of Science and Technology · RUSt Petersburg University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apart from their anti-inflammatory action, COX inhibitors have gathered the interest of many scientists due to their potential use for the treatment and prevention of cancer. It has been shown that cyclooxygenase inhibitors restrict cancer cell growth and are able to interact with known antitumor drugs, enhancing their in vitro and in vivo cytotoxicity. The permutation of hydrophilic and hydrophobic aryl groups in COX inhibitors leads to cardinal changes in the biological activity of the compounds. In the present study, thirteen heterocyclic coxib-like 4,5-diarylfuran-3(

Indexed as

Amino AcidsAmino Acid SequenceAnti-Inflammatory Agents, Non-SteroidalAntineoplastic AgentsCarrageenanCell Line, TumorCell SurvivalCyclooxygenase 2Cyclooxygenase 2 InhibitorsDrug DesignEdemaFluorineFuransHumansMolecular Docking SimulationMolecular StructureAmino AcidsAnti-Inflammatory Agents, Non-SteroidalAntineoplastic AgentsCarrageenanCyclooxygenase 2Cyclooxygenase 2 InhibitorsFluorineFurans3(2H)furanones5-fluorouracilanticancercyclooxygenasecytotoxicitygefitinibHSC-3MCF-7phenanthro[9,10-b]furanones

Identifiers

PMID31064095
PMCPMC6539231
OpenAlexW2942877092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.