ArticlePolymers2019
Hydrogel Small-Diameter Vascular Graft Reinforced with a Braided Fiber Strut with Improved Mechanical Properties.
Article in Polymers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Thermomechanical Tailoring of a DLP-Printable Shape Memory Polyurethane for Vascular Graft Applications.Materials (Basel, Switzerland) · 2026Article
- Biomimetic hydrogel design strategies for vascular grafts and vascularized tissue constructs.Frontiers in bioengineering and biotechnology · 2026Review
- Advancements in textile techniques for cardiovascular tissue replacement and repair.APL bioengineering · 2024Review
- Small-Diameter Blood Vessel Substitutes: Biomimetic Approaches to Improve Patency.Biomimetics (Basel, Switzerland) · 2024Review
- Recent Advances in Polymers as Matrices for Drug Delivery Applications.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Review of Polymeric Biomimetic Small-Diameter Vascular Grafts to Tackle Intimal Hyperplasia.ACS omega · 2022Review
- The Regulatory Effect of Braided Silk Fiber Skeletons with Differential Porosities on In Vivo Vascular Tissue Regeneration and Long-Term Patency.Research (Washington, D.C.) · 2022Article
- Development of drug loaded cardiovascular prosthesis for thrombosis prevention using 3D printing.Materials science & engineering. C, Materials for biological applications · 2021Article
- Dual Cross-Linked Chitosan/PVA Hydrogels Containing Silver Nanoparticles with Antimicrobial Properties.Pharmaceutics · 2021Article
- Use of 3D Printing for the Development of Biodegradable Antiplatelet Materials for Cardiovascular Applications.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Parametric Optimization of 3D Printed Hydrogel-Based Cardiovascular Stent.Pharmaceutical research · 2021Article
- Effects of Gelatin Methacrylate Bio-ink Concentration on Mechano-Physical Properties and Human Dermal Fibroblast Behavior.Polymers · 2020Article
- Article
- 3D Printing of Amino Resin-based Photosensitive Materials on Multi-parameter Optimization Design for Vascular Engineering Applications.Polymers · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
Abstract
Acute thrombosis remains the main limitation of small-diameter vascular grafts (inner diameter <6 mm) for bridging and bypassing of small arteries defects and occlusion. The use of hydrogel tubes represents a promising strategy. However, their low mechanical strength and high swelling tendency may limit their further application. In the present study, a hydrogel vascular graft of Ca alginate/polyacrylamide reinforced with a braided fiber strut was designed and fabricated with the assistance of a customized casting mold. Morphology, structure, swellability, mechanical properties, cyto- and hemocompatibility of the reinforced graft were characterized. The results showed that the reinforced graft was transparent and robust, with a smooth surface. Scanning electron microscopic examination confirmed a uniform porous structure throughout the hydrogel. The swelling of the reinforced grafts could be controlled to 100%, obtaining clinically satisfactory mechanical properties. In particular, the dynamic circumferential compliance reached (1.7 ± 0.1)%/100 mmHg for 50-90 mmHg, a value significantly higher than that of expanded polytetrafluoroethylene (ePTFE) vascular grafts. Biological tests revealed that the reinforced graft was non-cytotoxic and had a low hemolysis percentage (HP) corresponding to (0.9 ± 0.2)%. In summary, the braided fiber-reinforced hydrogel vascular grafts demonstrated both physical and biological superiority, suggesting their suitability for vascular grafts.
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Registered trials
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