ArticlePoultry science2019
A blend of fatty acids, organic acids, and phytochemicals induced changes in intestinal morphology and inflammatory gene expression in coccidiosis-vaccinated broiler chickens.
Article in Poultry science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Dietary biotic supplementation modulates growth performance, anticoccidial efficacy, oxidative status, and intestinal histomorphology in Eimeria tenella-challenged broilers.Poultry science · 2026Article
- Article
- Coccidiosis prevention strategies shape the microbiome, resistome and mobilome composition in the broiler gut.Animal microbiome · 2026Article
- Effect of microencapsulated organic acids-essential oils blend and protease on performance and gut health of broilers under nutritional challenges.Journal of animal science and technology · 2025Article
- Potential relationship between gut microbiota and animal diarrhea: a systematic review.Frontiers in microbiology · 2025Review
- The Interaction between Feed Bioactive Compounds and Chicken Genome.Animals : an open access journal from MDPI · 2023Review
- Protective effect of phytogenic plus short and medium-chain fatty acids-based additives in enterotoxigenic Escherichia coli challenged piglets.Veterinary research communications · 2023Article
- Effect of blending encapsulated essential oils and organic acids as an antibiotic growth promoter alternative on growth performance and intestinal health in broilers with necrotic enteritis.Poultry science · 2022Article
- Effect of organic acids on growth performance, intestinal morphology, and immunity of broiler chickens with and without coccidial challenge.AMB Express · 2021Article
- The in vitro and in vivo anti-virulent effect of organic acid mixtures against Eimeria tenella and Eimeria bovis.Scientific reports · 2021Article
- Effects of Microencapsulated Blends of Organics Acids (OA) and Essential Oils (EO) as a Feed Additive for Broiler Chicken. A Focus on Growth Performance, Gut Morphology and Microbiology.Animals : an open access journal from MDPI · 2020Article
- Protected Blend of Organic Acids and Essential Oils Improves Growth Performance, Nutrient Digestibility, and Intestinal Health of Broiler Chickens Undergoing an Intestinal Challenge.Frontiers in veterinary science · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Feed additives that promote gastrointestinal health may complement coccidiosis vaccination programs in antibiotic-free broiler production systems. This study examined the effects of a commercial feed additive blend (FA) on intestinal histomorphology and inflammatory biomarkers in vaccinated Ross 708 cockerels (N = 2,160). The study was a randomized complete block design (12 blocks) with 3 dietary treatments: CON (negative control), AGP (positive control: 55 ppm of bacitracin methylene disalicylate), and FA (1.5 kg/MT in starter; 1.0 kg/MT in grower; and 0.5 kg/MT in finisher). Birds were reared on re-used litter and fed a 3-phase feeding program (starter, 0 to 14 D; grower, 15 to 28 D; finisher, 29 to 36 D). One master batch of basal feed for each feeding phase was prepared and final experimental diets were manufactured by mixing the basal feed with the respective test ingredient prior to pelleting. Growth measurements, including pen body weight and feed intakes, and fresh fecal samples were taken throughout the study. On day 20, samples of intestinal tissue were collected from a subset of birds (n = 72, 1 block) for histomorphology and mRNA expression of tight junction and inflammatory genes. In the duodenum, the ratio of villi length to crypt depth was significantly lower in FA (and AGP) fed birds than those consuming the CON diet. Relative mRNA expressions of iNOS, IFNƔ, and claudin-1 were upregulated in the jejunum of FA and AGP treatment groups compared to those in the CON group; the response in the FA was of lesser magnitude than AGP. Together, these results demonstrated that the FA treatment altered the microstructure of the duodenum and affected the expression of inflammatory genes in the jejunum. The timing of these changes coincided with peak oocyte shedding in feces and an observed reduction in feed efficiency in all dietary treatment groups.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.