ArticleDevelopmental cell2019
Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1
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Article in Developmental cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
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Who cites it
39 citing papers in PubMed, 57 citations in OpenAlex.
- GTP biosynthesis is a therapeutic vulnerability in Rac1-mutant melanoma.bioRxiv : the preprint server for biology · 2026Article
- Delineation of signaling microdomains from live-cell movies.Cell systems · 2026Article
- Modulation of Oncogenic KRAS Signaling by Branched Actin-driven Cell Membrane Protrusions.Research square · 2026Article
- RhoG, Rac1 and Cdc42 cooperation in cell protrusion revealed by multiplexed optogenetics and biosensor imaging.bioRxiv : the preprint server for biology · 2026Article
- Modulation of Oncogenic KRAS Signaling by Branched Actin-driven Cell Membrane Protrusions.bioRxiv : the preprint server for biology · 2026Article
- Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibition.Oncogene · 2025Article
- New insights into the classification of the RAC1 P29S hotspot mutation in melanoma as an oncogene.Cancer gene therapy · 2025Article
- Elevated SNHG1 promotes invasion and migration of Cd(II)-transformed cells through Sox2, Rac1, and Slug.Toxicology and applied pharmacology · 2025Article
- Article
- Direct Arp2/3-vinculin binding is required for pseudopod extension, but only on compliant substrates and in 3D.iScience · 2025Article
- Morphological control of merlin-Rac antagonism in proliferation-promoting signaling.Science signaling · 2025Article
- Spatial proteomics of ER tubules reveals CLMN, an ER-actin tether at focal adhesions that promotes cell migration.Cell reports · 2025Article
- Vimentin filament transport and organization revealed by single-particle tracking and 3D FIB-SEM.The Journal of cell biology · 2025Article
- Identification of LIMK1 as a biomarker in clear cell renal cell carcinoma: from data mining to validation.Journal of cancer research and clinical oncology · 2025Article
- Review
- Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints.Oncogene · 2024Article
- Rac1 promotes kidney collecting duct repair by mechanically coupling cell morphology to mitotic entry.Science advances · 2024Article
- RhoA activation promotes glucose uptake to elevate proliferation in MAPK inhibitor resistant melanoma cells.bioRxiv : the preprint server for biology · 2024Article
- Understanding cancer drug resistance withiScience · 2023Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Ashwathi S MohanLyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Kevin M DeanDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Tadamoto IsogaiLyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Stacy Y KasitinonChildren's Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Vasanth S MuraliLyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Philippe RoudotLyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Alex GroismanDepartment of Physics, University of California, San Diego, La Jolla, CA 92093, USA.
Dana K ReedLyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Erik S WelfLyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Sangyoon J HanLyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USA.
Jungsik NohLyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Gaudenz DanuserLyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: gaudenz.danuser@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · USMichigan Technological University · USUniversity of California, San Diego · US
Funding
The Mechanics of Actin-mediated Cell ProtrusionR01GM071868 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI DANUSER, GAUDENZ · 2007 to 2020
$2.9MNascent Adhesion-Based Mechano-transmission for Extracellular Matrix Stiffness SensingR15GM135806 · NIGMS · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI HAN, SANGYOON JOSHUA · 2019 to 2024
$964kMechanisms of melanoma migration and survival in 3D microenvironmentsK25CA204526 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI WELF, ERIK S · 2016 to 2020
$585kTEM for UT Southwestern Electron Microscopy Core FacilityS10OD021685 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI LUBY-PHELPS, KATHERINE J · 2017 to 2017
$398kThe mechanical and biochemical mechanism of oncogenic Rac1P29S mutation in melanoma survival signalingF30CA206399 · NCI · WASHINGTON UNIVERSITY · PI MOHAN, ASHWATHI · 2017 to 2020
$128kSymmetry breaking and polarization of cell in 3D environmentsF32GM117793 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI DEAN, KEVIN MICHAEL · 2016 to 2017
$121kNCI NIH HHS F30 CA206399NCI NIH HHS K25 CA204526NIGMS NIH HHS F32 GM117793NIGMS NIH HHS R01 GM071868NIGMS NIH HHS R15 GM135806NIH HHS S10 OD021685
Abstract
Actin assembly supplies the structural framework for cell morphology and migration. Beyond structure, this actin framework can also be engaged to drive biochemical signaling programs. Here, we describe how the hyperactivation of Rac1 via the P29S mutation (Rac1
Indexed as
ActinsAnimalsCell Line, TumorCell MovementCell ProliferationDendritesDendritic CellsFemaleHeterograftsHumansMAP Kinase Signaling SystemMelanomaMiceMice, Inbred NODMice, SCIDMutationActinsrac1 GTP-Binding ProteinRAC1 protein, humanactin assemblylamellipodiamelanomamerlinNF2proliferationRac1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.