Evidence map›Paper›PMID 31063660›Full record

ArticleHepatology (Baltimore, Md.)2019

Long Noncoding RNA H19 Contributes to Cholangiocyte Proliferation and Cholestatic Liver Fibrosis in Biliary Atresia.

Yongtao Xiao, Runping Liu, Xiaojiaoyang Li, Emily C Gurley, Phillip B Hylemon, Ying Lu, Huiping Zhou, Wei Cai

Open access · greenAbstract read
In one paragraph

Article in Hepatology (Baltimore, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
17.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 146 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Biliary atresia-related liver fibrosis.Frontiers in cell and developmental biology · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Non-coding RNAs in alcohol-associated liver disease.Liver research (Beijing, China) · 2025
    Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yongtao XiaoDepartment of Pediatric Surgery, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Runping LiuDepartment of Microbiology and Immunology and McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, VA.
Xiaojiaoyang LiDepartment of Microbiology and Immunology and McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, VA.
Emily C GurleyDepartment of Microbiology and Immunology and McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, VA.
Phillip B HylemonDepartment of Microbiology and Immunology and McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, VA.
Ying LuDepartment of Pediatric Surgery, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Huiping ZhouDepartment of Microbiology and Immunology and McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, VA.ORCID 0000-0002-0050-372X
Wei CaiDepartment of Pediatric Surgery, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Virginia Commonwealth University · USShanghai Jiao Tong University · CN

Funding

Regulation of Hepatic SphK2 by Bile Acids: Effects on Lipid MetabolismR01DK057543 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI HYLEMON, PHILLIP B, ZHOU, HUIPING ROSE · 2001 to 2015
$4.4M
LncRNA H19 in Cholestatic Liver DiseasesR01DK115377 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI HYLEMON, PHILLIP B, ZHOU, HUIPING ROSE · 2018 to 2021
$2.1M
Bile Acid and Sphingosine-1-phosphate Receptor-mediated Signaling in CholestasisR01DK104893 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI HYLEMON, PHILLIP B, ZHOU, HUIPING ROSE · 2016 to 2020
$2.0M
Mechanisms of Berberine for the Treatment of Non-Alcoholic Fatty Liver DiseaseI01BX004033 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI ZHOU, HUIPING ROSE · 2018 to 2021
–
BLR&D Research Career Scientist Award ApplicationIK6BX004477 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI HUIPING ZHOU · 2019 to 2026
–
BLRD VA I01 BX001390BLRD VA I01 BX004033BLRD VA IK6 BX004477NIDDK NIH HHS R01 DK057543NIDDK NIH HHS R01 DK104893NIDDK NIH HHS R01 DK115377
6 · The paper itself

Abstract

Biliary atresia (BA) is a neonatal liver disease featuring cholestasis and severe liver fibrosis (LF). Despite advances in the development of surgical treatment, lacking an early diagnostic marker and intervention of LF invariably leads to death from end-stage liver disease in the early years of life. We previously reported that knockout of sphingosine 1-phosphate receptor 2 (S1PR2) protected mice from bile duct ligation (BDL)-induced cholangiocyte proliferation and LF. Our recent studies further showed that both hepatic and serum exosomal long noncoding RNA H19 (lncRNAH19) levels are correlated with cholestatic injury in multidrug resistance 2 knockout (Mdr2

Indexed as

Cell ProliferationAnimalsBile DuctsBiliary AtresiaCells, CulturedCholestasisEpithelial CellsExosomesFemaleHumansInfantLiver CirrhosisMaleMiceRNA, Long NoncodingH19 long non-coding RNARNA, Long Noncoding

Identifiers

PMID31063660
PMCPMC6819224
OpenAlexW2944228278

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.