ArticleJournal of thrombosis and haemostasis : JTH2019
Assessment of the analytical performances and sample stability on ST Genesia system using the STG-DrugScreen application.
Article in Journal of thrombosis and haemostasis : JTH, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05422157 (Evaluation of the Inter-center Variability of the Measurement of Thrombin Generation by the ST Genesia System), which is not on this map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Inter-center Variability of the Measurement of Thrombin Generation by the ST Genesia System
Who cites it
26 citing papers in PubMed.
- Multicenter Interlaboratory Study of Thrombin Generation Assay in Healthy Adults Using the ST Genesia Analyzer With the STG-ThromboScreen Reagent (With and Without Thrombomodulin).International journal of laboratory hematology · 2026Observational
- Impact of blood collection tubes on thrombin generation assay results: a comparison of citrate and CTAD.Scientific reports · 2026Article
- Cost-effective screening strategy to prevent venous thromboembolism in combined oral contraceptive users.Frontiers in endocrinology · 2025Article
- How to assess hypercoagulability in heparin-induced thrombocytopenia? Biomarkers of potential value to support therapeutic intensity of non-heparin anticoagulation.Thrombosis journal · 2023Article
- Thrombin generation, bleeding and hemostasis in humans: Protocol for a scoping review of the literature.PloS one · 2023Article
- Evaluation of Activated Protein C Resistance Using Thrombin Generation Test.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Comparison of analytical performances between clot waveform analysis and FibWave in edoxaban-treated patients and healthy controls.Research and practice in thrombosis and haemostasis · 2022Article
- Applicability of the Thrombin Generation Test to Evaluate the Hemostatic Status of Hemophilia A Patients in Daily Clinical Practice.Journal of clinical medicine · 2022Article
- Analytical performance of the endogenous thrombin potential-based activated protein C resistance assay on the automated ST Genesia system.Research and practice in thrombosis and haemostasis · 2022Article
- Thrombin generation measured on ST Genesia, a new platform in the coagulation routine lab: Assessment of analytical and between-subject variation.Research and practice in thrombosis and haemostasis · 2022Article
- Semi-automated thrombin dynamics applying the ST Genesia thrombin generation assay.Frontiers in cardiovascular medicine · 2022Article
- Comparison of Acquired Activated Protein C Resistance, Using the CAT and ST-GenesiaJournal of clinical medicine · 2021Article
- Interlaboratory variability of activated protein C resistance using the ETP-based APC resistance assay.Research and practice in thrombosis and haemostasis · 2021Article
- Calibrated automated thrombogram II: removing barriers for thrombin generation measurements.Thrombosis journal · 2021Article
- Comparison is not reason: Pitfalls in reporting thrombin generation results in anticoagulated patients.Research and practice in thrombosis and haemostasis · 2021Article
- Anticoagulated patients exhibit intact endogenous thrombin potential using ST Genesia unlike the Calibrated Automated Thrombogram.Research and practice in thrombosis and haemostasis · 2021Article
- Thrombocytopathies: Not Just Aggregation Defects-The Clinical Relevance of Procoagulant Platelets.Journal of clinical medicine · 2021Review
- ST Genesia reference values of 117 healthy donors measured with STG-BleedScreen, STG-DrugScreen and STG-ThromboScreen reagents.Research and practice in thrombosis and haemostasis · 2021Article
- Validation of the Role of Thrombin Generation Potential by a Fully Automated System in the Identification of Breast Cancer Patients at High Risk of Disease Recurrence.TH open : companion journal to thrombosis and haemostasis · 2021Article
- Prothrombotic hemostasis disturbances in patients with severe COVID-19: Individual daily data.Data in brief · 2020Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThrombin generation testing has been used to provide information on the coagulation phenotype of patients. The most used technique is the calibrated automated thrombogram (CAT) but it suffers from a lack of standardization, preventing its implementation in routine. The ST Genesia is a new analyzer designed to assess thrombin generation based on the same principle as the CAT. Unlike the CAT system, the ST Genesia is a benchtop, fully automated analyzer, able to perform the analyses individually and not by batch, with strict control of variables such as temperature and volumes, ensuring, theoretically, maximal reproducibility.
objectivesThis study aimed at assessing the performance of the STG-DrugScreen application on the ST Genesia analyzer. We also aimed at exploring stability of plasma samples after freezing and defining a reference normal range.
resultsResults demonstrated the excellent interexperiment precision of the ST Genesia and confirmed that the use of a reference plasma helps reducing the inter-experiments variability. Stability revealed that plasma samples are stable for at least 11 months at -70°C or lower, except for those containing low molecular weight heparins which have to be tested within 6 months. Freezing had no effect on the majority of thrombin generation parameters except on time to peak.
conclusionsOur results suggest an easy implementation of thrombin generation with the use of ST Genesia in the routine laboratory. This will facilitate the design of multicentric studies and enable the establishment of reliable and evidence-based thresholds, which may improve the management of patients treated with anticoagulants.
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Registered trials
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