Evidence map›Paper›PMID 31063550›Full record

Trial reportNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2020

Opioid Use and Rate of Nicotine Metabolism Among Pregnant Smokers.

Cheryl Oncken, Erin L Mead, Ellen A Dornelas, Chia-Ling Kuo, Heather Z Sankey, Henry R Kranzler, Sheila Thurlow

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Pregnant Smokers Receiving Opioid Agonist Therapy Have an Elevated Nicotine Metabolite Ratio: A Replication Study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Cheryl OnckenDepartment of Medicine, University of Connecticut School of Medicine, Farmington, CT.
Erin L MeadDepartment of Medicine, University of Connecticut School of Medicine, Farmington, CT.
Ellen A DornelasDivision of Oncology, Department of Medicine, Hartford Hospital, Hartford, CT.
Chia-Ling KuoDepartment of Medicine, University of Connecticut School of Medicine, Farmington, CT.
Heather Z SankeyDepartment of Obstetrics and Gynecology, UMMS-Baystate, Springfield, MA.
Henry R KranzlerDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine and Crescenz VAMC, Philadelphia, PA.
Sheila ThurlowDepartment of Medicine, University of Connecticut School of Medicine, Farmington, CT.
University of Connecticut · USBaystate Health · USHartford Hospital · USPhiladelphia VA Medical Center · US

Funding

Nicotine Replacement for Smoking Cessation During PregnancyR01HD069314 · NICHD · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI ONCKEN, CHERYL A · 2011 to 2016
$3.2M
NICHD NIH HHS R01 HD069314
6 · The paper itself

Abstract

introductionSmokers who use opioids smoke more cigarettes per day (CPD) than non-opioid users, which could be due to the effects of opioids on nicotine metabolism. Moreover, nicotine metabolism increases during pregnancy, potentially making quitting more difficult for pregnant smokers. We examined nicotine metabolism and its association with opioid use (OU) and CPD in pregnant smokers.

methodsWe recruited pregnant women who smoked at least 5 CPD for a clinical trial of smoking cessation. Plasma nicotine metabolite ratio (NMR; trans-3'-hydroxycotinine (3HC)/cotinine)-a biomarker of nicotine metabolism-OU (involving methadone, buprenorphine, fentanyl, oxycodone, or tramadol), and CPD were assessed at baseline. We used linear regression to examine the associations between log-transformed NMR, OU, and CPD, adjusting for race/ethnicity and menthol smoking.

resultsAmong 129 pregnant smokers, 25 (19%) were opioid users; most were maintained on methadone (n = 14). Compared to non-OU smokers, OU smokers had higher median CPD (10.0 vs. 7.0, p = .0007), serum 3HC (81.0 vs. 42.0 ng/mL, p = .0001), and NMR (0.63 vs. 0.43, p < .0001). In addition, methadone-maintained smokers had a higher median NMR than non-OU smokers (0.66 vs. 0.43, p = .0004). Adjusting for covariates, log-transformed NMR was greater in OU smokers (p = .012), specifically methadone-maintained smokers (p = .024), than non-OU smokers.

conclusionsOur preliminary results show that OU is associated with a higher NMR in pregnant smokers. A larger study sample is needed to replicate this finding, examine potential mechanisms, and determine its clinical significance. IMPLICATIONS: Among pregnant smokers, we observed that nicotine metabolism was significantly faster among opioid users-the majority of whom were on methadone maintenance-compared to nonusers, which could have implications for smoking cessation. Further studies are needed to replicate this finding, evaluate potential mechanisms, and determine its clinical significance.

Indexed as

AdultAnalgesics, OpioidBiomarkersCase-Control StudiesFemaleHumansNicotineNon-SmokersOpioid-Related DisordersPregnancySmokersSmokingSmoking CessationYoung AdultAnalgesics, OpioidBiomarkersNicotine

Identifiers

PMID31063550
PMCPMC7249922
OpenAlexW2943900148

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.