ArticleActa crystallographica. Section D, Structural biology2019
Design guidelines for an electron diffractometer for structural chemistry and structural biology.
Article in Acta crystallographica. Section D, Structural biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Practical crystallography with a transmission electron microscope.Journal of microscopy · 2026Article
- Computational methods for automated center determination in electron diffraction patterns.Journal of applied crystallography · 2026Article
- Reuniting crystallography with real space: Ab initio structure elucidation with 4D-STEM.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- How to use DIALS to process chemical crystallography 3D ED rotation data from pixel array detectors.Acta crystallographica. Section C, Structural chemistry · 2025Article
- Electron crystallography and dedicated electron-diffraction instrumentation.Acta crystallographica. Section E, Crystallographic communications · 2023Article
- Article
- Electron Diffraction of 3D Molecular Crystals.Chemical reviews · 2022Review
- 3D Electron Diffraction for Chemical Analysis: Instrumentation Developments and Innovative Applications.Chemical reviews · 2021Review
- Ab Initio Determination of Peptide Structures by MicroED.Methods in molecular biology (Clifton, N.J.) · 2021Article
- A shared vision for macromolecular crystallography over the next five years.Structural dynamics (Melville, N.Y.) · 2019Article
- 3D-structured supports create complete data sets for electron crystallography.Nature communications · 2019Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
3D electron diffraction has reached a stage where the structures of chemical compounds can be solved productively. Instrumentation is lagging behind this development, and to date dedicated electron diffractometers for data collection based on the rotation method do not exist. Current studies use transmission electron microscopes as a workaround. These are optimized for imaging, which is not optimal for diffraction studies. The beam intensity is very high, it is difficult to create parallel beam illumination and the detectors used for imaging are of only limited use for diffraction studies. In this work, the combination of an EIGER hybrid pixel detector with a transmission electron microscope to construct a productive electron diffractometer is described. The construction not only refers to the combination of hardware but also to the calibration of the system, so that it provides rapid access to the experimental parameters that are necessary for processing diffraction data. Until fully integrated electron diffractometers become available, this describes a setup for productive and efficient operation in chemical crystallography.
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Registered trials
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