ArticleeLife2019
Dissociable laminar profiles of concurrent bottom-up and top-down modulation in the human visual cortex.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Frequency and laminar profile of feature-specific visual activity revealed by interleaved EEG-fMRI.eLife · 2026Article
- Distinct Roles of Deep and Superficial Cortical Layers in Tone Prediction, Comparison, and Adaptation in Human Auditory Cortices.Nature communications · 2026Article
- UltraFast Layer-Resolved Encoding (uFLARE) functional MRI deciphers bidirectional signaling from spontaneous activity.Nature communications · 2026Article
- Bridging the gap with invasive imaging: promises and challenges of a new generation of ultrahigh resolution fMRI.bioRxiv : the preprint server for biology · 2026Article
- Layer-specific attentional modulation in the human primary somatosensory cortex.Nature communications · 2026Article
- Article
- The potential of laminar functional MRI in refining the understanding of epilepsy in humans.Brain : a journal of neurology · 2025Review
- The superficial layers of the primary visual cortex create a saliency map that feeds forward to the parietal cortex.PLoS biology · 2025Article
- In silico discovery of representational relationships across visual cortex.Nature human behaviour · 2025Article
- Article
- Layer-specific spatiotemporal dynamics of feedforward and feedback in human visual object perception.bioRxiv : the preprint server for biology · 2025Article
- Fronto-occipital dyscommunication associates with brain hierarchy in schizophrenia.Communications biology · 2025Article
- Characterizing BOLD activation patterns in the human hippocampus with laminar fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- How Layer-Specific fMRI Can Contribute to Understanding Perceptual Disturbances Across Psychiatric Disorders.Current topics in behavioral neurosciences · 2025Review
- Multilayer network analysis across cortical depths in 7-T resting-state fMRI.Network neuroscience (Cambridge, Mass.) · 2025Article
- Multilayer Network Analysis across Cortical Depths in Resting-State 7T fMRI.bioRxiv : the preprint server for biology · 2024Article
- Dynamic layer-specific processing in the prefrontal cortex during working memory.Communications biology · 2024Article
- Evaluating the effect of denoising submillimeter auditory fMRI data with NORDIC.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Laminar dissociation of feedforward and feedback in high-level ventral visual cortex during imagery and perception.iScience · 2024Article
- Collective plasticity of binocular interactions in the adult visual system.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Recent developments in human neuroimaging make it possible to non-invasively measure neural activity from different cortical layers. This can potentially reveal not only which brain areas are engaged by a task, but also how. Specifically, bottom-up and top-down responses are associated with distinct laminar profiles. Here, we measured lamina-resolved fMRI responses during a visual task designed to induce concurrent bottom-up and top-down modulations via orthogonal manipulations of stimulus contrast and feature-based attention. BOLD responses were modulated by both stimulus contrast (bottom-up) and by engaging feature-based attention (top-down). Crucially, these effects operated at different cortical depths: Bottom-up modulations were strongest in the middle cortical layer and weaker in deep and superficial layers, while top-down modulations were strongest in the superficial layers. As such, we demonstrate that laminar activity profiles can discriminate between concurrent top-down and bottom-up processing, and are diagnostic of how a brain region is activated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.