Trial reportInternational journal of laboratory hematology2019
Establishing a reference range for thromboelastograph parameters in the neonatal period.
Trial report in International journal of laboratory hematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- The use of thromboelastography (TEG) and rotational thromboelastometry (ROTEM) in neonates: a systematic review.European journal of pediatrics · 2021Pooled it
- Establishing a reference range for thromboelastograph parameters in the neonatal period.International journal of laboratory hematology · 2019Trial
- Management of neonatal massive hemorrhage: A narrative review.Transfusion · 2026Review
- Unveiling the Hemostatic Signature of Prematurity: A Prospective Rotational Thromboelastometry-Based Analysis.Medicina (Kaunas, Lithuania) · 2025Article
- Thromboelastometry-Based Profiling of Haemostatic Alterations in Neonatal Sepsis by Causative Pathogens.Antibiotics (Basel, Switzerland) · 2025Article
- Effects of fascial manipulation, vibration exercise, motor imagery, or neuro-muscular electrical stimulation on the coagulation system: A pilot study.Physiological reports · 2025Article
- The Role of Rotational Thromboelastometry in Early Detection of the Hemostatic Derangements in Neonates with Systemic Candida Infection.Journal of fungi (Basel, Switzerland) · 2024Article
- Viscoelastic coagulation testing in Neonatal Intensive Care Units: advantages and pitfalls in clinical practice.Blood transfusion = Trasfusione del sangue · 2023Review
- Reference Values of Thromboelastometry Parameters in Healthy Term Neonates Using NATEM in Cord Blood Samples.Children (Basel, Switzerland) · 2022Article
- TEGDiagnostics (Basel, Switzerland) · 2021Review
- Pediatric Fibrinogen PART I-Pitfalls in Fibrinogen Evaluation and Use of Fibrinogen Replacement Products in Children.Frontiers in pediatrics · 2021Review
- Establishment of Normal Range for Thromboelastography in Healthy Middle-Aged and Elderly People of Weihai in China.Journal of healthcare engineering · 2021Article
- Capillary blood reference intervals for platelet parameters in healthy full-term neonates in China.BMC pediatrics · 2020Article
- Establishing a reference range for thromboelastography maximum amplitude in patients administrating with antiplatelet drugs.Journal of clinical laboratory analysis · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
introductionAcquired coagulation disorders are a common cause of neonatal bleeding. The thromboelastograph (TEG) comprehensively assesses haemostatic processes in the body. Unfortunately, the reference range of TEG parameters in the neonatal period has not yet been evaluated, which limits the use of the TEG in neonates. In this study, we aimed to establish the reference range of TEG parameters for the neonatal period.
methodsThis study included 371 full-term infants (≥37 weeks of gestation), and we divided these infants into three groups according to age as follows: 1, 2-7 and 8-28 days. We measured their peripheral blood using TEG, coagulation routine and platelet count tests. We analysed differences among the groups.
resultsThe reference ranges for TEG parameters are presented as medians and reference ranges (2.5th and 97.5th percentiles) as follows: R (clot reaction time, seconds) 4.80 (2.80-7.17), Angle (fibrin production rate) 69.90 (44.91-78.89), K (clot kinetics, min) 1.40 (0.80-4.50), MA (maximum amplitude, mm) 63.50(44.34-74.66) and LY30 (lysis at 30 minutes, %) 0.10 (0.10-6.95). There were significant differences in Angle, K, MA and LY30 values between the different neonatal day age groups.
conclusionThis study preliminarily establishes a reference range for TEG parameters during the neonatal period. The age of a newborn had a large influence on TEG parameters. Additionally, we demonstrated a correlation between laboratory tests and TEG parameters for this age period. The reference values provided herein are meaningful for future studies.
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