ArticleChemistry (Weinheim an der Bergstrasse, Germany)2019
Enantio- and Diastereoswitchable C-H Arylation of Methylene Groups in Cycloalkanes.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 28 citations in OpenAlex.
- Synthesis of Chiral Saturated Heterocycles Bearing Quaternary Centers via Enantioselective β-C(spJournal of the American Chemical Society · 2025Article
- Synthetic techniques for thermodynamically disfavoured substituted six-membered rings.Nature reviews. Chemistry · 2024Review
- Enantioselective remote methylene C-H (hetero)arylation of cycloalkane carboxylic acids.Science (New York, N.Y.) · 2024Article
- Article
- Palladium-Catalyzed Enantioselective β-C(spAccounts of chemical research · 2022Article
- Transition-Metal-Catalyzed, Coordination-Assisted Functionalization of Nonactivated C(spChemical reviews · 2021Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
A complementary set of chiral N,N-ligands enables the Pd-catalyzed β-C-H arylation of unbiased internal methylene groups in good yield and with high levels of enantio- and diastereoinduction. Both the dia- and enantioselectivity can be reversed, thus allowing the selective arylation of any of the four β-C-H bonds in cycloalkanecarboxamides of various ring sizes. The method is applicable to a broad range of aryl iodides with electron-withdrawing and -donating substituents in the o-, m-, or p-position.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.