ArticleAlcohol and alcoholism (Oxford, Oxfordshire)2019
Effects of Alcohol Consumption on Pair Bond Maintenance and Potential Neural Substrates in Female Prairie Voles.
Article in Alcohol and alcoholism (Oxford, Oxfordshire), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Voluntary exercise is a moderately effective mitigator of chronic social isolation stress in two female rodent models.Physiology & behavior · 2025Article
- Male-selective effects of oxytocin agonism on alcohol intake: behavioral assessment in socially housed prairie voles and involvement of RAGE.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Conditioned social preference and reward value of activating oxytocin-receptor-expressing ventral tegmental area neurons following repeated daily binge ethanol intake.Alcoholism, clinical and experimental research · 2022Article
- Alcohol and oxytocin: Scrutinizing the relationship.Neuroscience and biobehavioral reviews · 2021Review
- A Neuroscientist's Guide to the Vole.Current protocols · 2021Article
- Oxytocin treatment for alcoholism: Potential neurocircuitry targets.Neuropharmacology · 2020Review
- Biparental care in C57BL/6J mice: effects on adolescent behavior and alcohol consumption.Psychopharmacology · 2020Article
- Effects of Housing Conditions and Circadian Time on Baseline c-Fos Immunoreactivity in C57BL/6J Mice.Neuroscience · 2020Article
- Involvement of Centrally Projecting Edinger-Westphal Nucleus Neuropeptides in Actions of Addictive Drugs.Brain sciences · 2020Review
- Sex Differences in Value-Based Decision Making Underlie Substance Use Disorders in Females.Alcohol and alcoholism (Oxford, Oxfordshire) · 2019Article
- The Prairie Vole Model of Pair-Bonding and Its Sensitivity to Addictive Substances.Frontiers in psychology · 2019Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
aimsDiscordant heavy alcohol use is a risk factor for disruption of intimate partner relationships. Modeling these relationships in prairie voles indicates that biological effects of alcohol can contribute to this risk. In particular, alcohol consumption disrupted an established preference for a female partner in male prairie voles if the partner was drinking water, but not if the partner was drinking alcohol. The current study investigated the effects of alcohol consumption on pair bonds in female prairie voles.
methodsFemale and male prairie voles established pair bonds during 1 week of cohabitation. Following cohabitation, females and their partners were put into mesh-divided cages where they were given access to 10% ethanol and water or only water for 1 week. Pair bonds in female prairie voles were tested using the partner preference test (PPT). Following the PPT, we examined oxytocin, vasopressin and FosB immunoreactivity across several brain regions.
resultsFemale prairie voles consumed more alcohol if their male partner was also drinking alcohol, but not if their partner was drinking water. During PPT, females preferred their partner over a stranger, regardless of their partner's drinking status. Alcohol consumption decreased oxytocin immunoreactivity in the paraventricular nucleus of the hypothalamus and increased FosB immunoreactivity in the centrally projecting Edinger-Westphal nucleus.
conclusionsEstablished partner preference in female prairie voles is resistant to alcohol consumption. This finding suggests that the risk for disruption of intimate partner relationships in females is not mediated by a decreased motivation to be with their partners.
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