ArticleAddiction biology2020
Transient synaptic potentiation in nucleus accumbens shell during refraining from cocaine seeking.
Article in Addiction biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Synaptic plasticity in cocaine-seeking ensembles of the nucleus accumbens core.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Functional and Structural Plasticity in Cocaine-Seeking Ensembles of the Nucleus Accumbens Core.bioRxiv : the preprint server for biology · 2025Article
- Cell-type specific synaptic plasticity in dorsal striatum is associated with punishment-resistance compulsive-like cocaine self-administration in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Cocaine-induced projection-specific and cell type-specific adaptations in the nucleus accumbens.Molecular psychiatry · 2022Review
- Circuit selectivity in drug versus natural reward seeking behaviors.Journal of neurochemistry · 2021Review
- Cocaine and sucrose rewards recruit different seeking ensembles in the nucleus accumbens core.Molecular psychiatry · 2020Article
- Psychostimulant-Induced Adaptations in Nucleus Accumbens Glutamatergic Transmission.Cold Spring Harbor perspectives in medicine · 2020Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
Repeated exposure to drug-associated cues without reward (extinction) leads to refraining from drug seeking in rodents. We determined if refraining is associated with transient synaptic plasticity (t-SP) in nucleus accumbens shell (NAshell), akin to the t-SP measured in the NAcore during cue-induced reinstatement of drug seeking. Using whole cell patch electrophysiology, we found that medium spiny neurons (MSNs) in NAshell expressed increased ratio of AMPA to NMDA glutamate receptor currents during refraining, which normalized to baseline levels by the end of the 2-hour extinction session. Unlike t-SP observed in NAcore during reinstated drug seeking, neither dendrite spine head enlargement nor activation of matrix metalloproteases (MMP2/9) accompanied the increased AMPA:NMDA in NAshell during refraining. Refraining was also not associated with changes in paired pulse ratio, NMDA receptor current decay time, or AMPA receptor rectification index in NAshell MSNs. Our preliminary data in transgenic mice suggest that t-SP may increase D2-MSN inputs relative to D1-MSN inputs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.