Evidence map›Paper›PMID 31062445›Full record

ArticleTropical medicine & international health : TM & IH2019

Varicella in Tshuapa Province, Democratic Republic of Congo, 2009-2014.

Jessica Leung, Andrea M McCollum, Kay Radford, Christine Hughes, Adriana S Lopez, Sarah Anne J Guagliardo, Beatrice Nguete, Toutou Likafi, Joelle Kabamba, Jean Malekani and 8 more

Open access · greenAbstract read
In one paragraph

Article in Tropical medicine & international health : TM & IH, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. A comprehensive review of monkeypox virus and mpox characteristics.Frontiers in cellular and infection microbiology · 2024
    Review
  8. Biological Characteristics and Pathogenesis of Monkeypox Virus: An Overview.Advances in experimental medicine and biology · 2024
    Review
  9. Mimics of Monkeypox: Considerations for the emergency medicine clinician.The American journal of emergency medicine · 2023
    Review
  10. Review
  11. Think outside the pox.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023
    Article
  12. Article
  13. Article
  14. Enhanced surveillance of monkeypox in Bas-Uélé, Democratic Republic of Congo: the limitations of symptom-based case definitions.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 2 countries.

Jessica LeungNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Andrea M McCollumNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Kay RadfordNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Christine HughesNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Adriana S LopezNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Sarah Anne J GuagliardoNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Beatrice NgueteKinshasa School of Public Health, Kinshasa, Democratic Republic of Congo.
Toutou LikafiKinshasa School of Public Health, Kinshasa, Democratic Republic of Congo.
Joelle KabambaU.S. Centers for Disease Control and Prevention, Kinshasa, Democratic Republic of Congo.
Jean MalekaniDepartment of Biology, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Robert Shongo LushimaMinistry of Health, Kinshasa, Democratic Republic of Congo.
Elisabeth PukutaInstitut National de Recherche Biomédicale, Kinshasa, Democratic Republic of Congo.
Stomy KarhemereInstitut National de Recherche Biomédicale, Kinshasa, Democratic Republic of Congo.
Jean Jacques Muyembe TamfumInstitut National de Recherche Biomédicale, Kinshasa, Democratic Republic of Congo.
Mary G ReynoldsNational Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Emile Wemakoy OkitolondaKinshasa School of Public Health, Kinshasa, Democratic Republic of Congo.
D Scott SchmidNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Mona MarinNational Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Centers for Disease Control and Prevention · USMinistry of Public Health · CDNational Institute of Biomedical Research · CDNational Center for Emerging and Zoonotic Infectious Diseases · USNational Center for Immunization and Respiratory Diseases · USUniversity of Kinshasa · CD

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

objectiveTo describe varicella cases in Tshuapa Province of the Democratic Republic of the Congo identified during monkeypox surveillance.

methodsDemographic, clinical and epidemiological data were collected from each suspected monkeypox case 2009-2014. Samples were tested by PCR for both Orthopoxviruses and varicella-zoster virus (VZV); a subset of VZV-positive samples was genotyped. We defined a varicella case as a rash illness with laboratory-confirmed VZV.

resultsThere were 366 varicella cases were identified; 66% were ≤19 years old. Most patients had non-typical varicella rash with lesions reported as the same size and stage of evolution (86%), deep and profound (91%), on palms of hands and/or soles of feet (86%) and not itchy (49%). Many had non-typical signs and symptoms, such as lymphadenopathy (70%) and sensitivity to light (23%). A higher proportion of persons aged ≥20 years than persons aged ≤19 years had ≥50 lesions (79% vs. 65%, P = 0.007) and were bedridden (15% vs. 9%, P = 0.056). All VZV isolates genotyped from 79 varicella cases were clade 5. During the surveillance period, one possible VZV-related death occurred in a 7-year-old child.

conclusionsA large proportion of patients presented with non-typical varicella rash and clinical signs and symptoms, highlighting challenges identifying varicella in an area with endemic monkeypox. Continued surveillance and laboratory diagnosis will help in rapid identification and control of both monkeypox and varicella and improve our understanding of varicella epidemiology in Africa.

Indexed as

AdolescentAdultAgedAged, 80 and overChickenpoxChildChild, PreschoolDemocratic Republic of the CongoFemaleHumansInfantMaleMiddle AgedMpox, MonkeypoxPolymerase Chain ReactionYoung AdultAfricaAfriquechickenpoxDemocratic Republic of Congo, DRCÉpidémiologieepidemiologymonkeypoxRDCRépublique Démocratique du Congovaricellavaricella-zoster virusvaricellevariole du singe monkeypoxvirus varicelle-zona

Identifiers

PMID31062445
PMCPMC8786670
OpenAlexW2944551834

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.