Evidence map›Paper›PMID 31062373›Full record

ArticleJournal of clinical pharmacology2019

Influence of Calcineurin Inhibitor and Sex on Mycophenolic Acid Pharmacokinetics and Adverse Effects Post-Renal Transplant.

Calvin J Meaney, Patcharaporn Sudchada, Joseph D Consiglio, Gregory E Wilding, Louise M Cooper, Rocco C Venuto, Kathleen M Tornatore

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Calvin J MeaneyImmunosuppressive Pharmacology Research Program, Translational Pharmacology Research Core, Buffalo, NY, USA.ORCID 0000-0003-2213-693X
Patcharaporn SudchadaImmunosuppressive Pharmacology Research Program, Translational Pharmacology Research Core, Buffalo, NY, USA.
Joseph D ConsiglioDepartment of Biostatistics, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA.
Gregory E WildingDepartment of Biostatistics, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA.
Louise M CooperImmunosuppressive Pharmacology Research Program, Translational Pharmacology Research Core, Buffalo, NY, USA.
Rocco C VenutoDepartment of Medicine; Nephrology Division, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Kathleen M TornatoreImmunosuppressive Pharmacology Research Program, Translational Pharmacology Research Core, Buffalo, NY, USA.ORCID 0000-0003-2028-4998
Nutrition Sciences (Belgium) · BEUniversity at Buffalo, State University of New York · USJacobs Institute · US

Funding

Age and Race Influences on Immunosuppression after Renal TransplantR01AG056392 · NIA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI TORNATORE, KATHLEEN M · 2018 to 2022
$3.5M
Genomic and Cellular Markers and Chronic Renal Allograft FunctionR21DK077325 · NIDDK · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI TORNATORE, KATHLEEN M · 2009 to 2010
$427k
NIA NIH HHS R01 AG056392NIDDK NIH HHS R21 DK077325
6 · The paper itself

Abstract

Tacrolimus or cyclosporine is prescribed with mycophenolic acid posttransplant and contributes to interpatient variability in mycophenolic acid pharmacokinetics and response. Cyclosporine inhibits enterohepatic circulation of the metabolite mycophenolic acid glucuronide, which is not described with tacrolimus. This study investigated mycophenolic acid pharmacokinetics and adverse effects in stable renal transplant recipients and the association with calcineurin inhibitors, sex, and race. Mycophenolic acid and mycophenolic acid glucuronide area under the concentration-time curve from 0 to 12 hours (AUC

Indexed as

Antibiotics, AntineoplasticArea Under CurveCalcineurin InhibitorsCyclosporineDrug InteractionsEnterohepatic CirculationFemaleHumansImmunosuppressive AgentsKidneyKidney TransplantationLymphopeniaMaleMiddle AgedMycophenolic AcidTacrolimusAntibiotics, AntineoplasticCalcineurin InhibitorsCyclosporineImmunosuppressive AgentsMycophenolic AcidTacrolimuscalcineurin inhibitorenterohepatic circulationmycophenolic acidpharmacokinetics

Identifiers

PMID31062373
PMCPMC7375007
OpenAlexW2943985746

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.