ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2019
Comparison and Selection of Current Implantable Anti-Epileptic Devices.
Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neurostimulation in children with drug-resistant epilepsy: strategies in subcortical targeting and systematic review of the evidence.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Pooled it
- Neuromodulation in Pediatric Epilepsy: When All Is Not About Resection-A Review.Epilepsy currents · 2026Article
- Dataset of chronic intracranial EEG of epilepsy patients via responsive neurostimulation system.Frontiers in neuroscience · 2026Article
- Review
- Invasive Neurostimulation for the Treatment of Epilepsy.Seminars in neurology · 2025Review
- Long-Term Ambulatory Intracranial EEG.Stereotactic and functional neurosurgery · 2025Review
- The role of neuromodulation in the management of drug-resistant epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Review
- Neurostimulation treatments for epilepsy: Deep brain stimulation, responsive neurostimulation and vagus nerve stimulation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- A retrospective, naturalistic study of deep brain stimulation and vagal nerve stimulation in young patients.Brain and behavior · 2024Article
- Vagus nerve stimulation: a physical therapy with promising potential for central nervous system disorders.Frontiers in neurology · 2024Review
- Chronic subthreshold cortical stimulation: A promising therapy for motor cortex seizures.Epilepsy & behavior reports · 2024Article
- Infraclavicular de novo placement of a responsive neurostimulator for a patient with eloquent glioma-associated epilepsy: illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- Resting state functional connectivity demonstrates increased segregation in bilateral temporal lobe epilepsy.Epilepsia · 2023Article
- Responsive Neurostimulation for Seizure Control: Current Status and Future Directions.Biomedicines · 2022Review
- Anterior nucleus of the thalamus deep brain stimulation vs temporal lobe responsive neurostimulation for temporal lobe epilepsy.Epilepsia · 2022Article
- Optimized Design of a Self-Biased Amplifier for Seizure Detection Supplied by Piezoelectric Nanogenerator: Metaheuristic Algorithms versus ANN-Assisted Goal Attainment Method.Micromachines · 2022Article
- Responsive Thalamic Neurostimulation: A Systematic Review of a Promising Approach for Refractory Epilepsy.Frontiers in human neuroscience · 2022Review
- Three dimensional microelectrodes enable high signal and spatial resolution for neural seizure recordings in brain slices and freely behaving animals.Scientific reports · 2021Article
- Neuromodulation in Drug Resistant Epilepsy.Aging and disease · 2021Review
- The surgical treatment of epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Implantable neural stimulators represent an advanced treatment adjunct to medication for pharmacoresistant epilepsy and alternative for patients that are not good candidates for resective surgery. Three treatment modalities are currently FDA-approved: vagus nerve stimulation, responsive neurostimulation, and deep brain stimulation. These devices were originally trialed in very similar patient populations with focal epilepsy, but head-to-head comparison trials have not been performed. As such, device selection may be challenging due to large overlaps in clinical indications and efficacy. Here we will review the data reported in the original pivotal clinical trials as well as long-term experience with these technologies. We will highlight differences in their features and mechanisms of action which may help optimize device selection on a case-by-case basis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.