Evidence map›Paper›PMID 31062205›Full record

ArticleMolecular and cellular pediatrics2019

Vitamin D supplementation after the second year of life: joint position of the Committee on Nutrition, German Society for Pediatric and Adolescent Medicine (DGKJ e.V.), and the German Society for Pediatric Endocrinology and Diabetology (DGKED e.V.).

Thomas Reinehr, Dirk Schnabel, Martin Wabitsch, Susanne Bechtold-Dalla Pozza, Christoph Bührer, Bettina Heidtmann, Frank Jochum, Thomas Kauth, Antje Körner, Walter Mihatsch and 6 more

Open access · goldAbstract read
In one paragraph

Article in Molecular and cellular pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. [Importance and supply of micronutrients in infants, children and adolescents].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2025
    Article
  2. Review
  3. Article
  4. Review
  5. Approach to Rickets: Is It Calciopenic or Phosphopenic?Turkish archives of pediatrics · 2023
    Article
  6. Article
  7. Article
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  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 11 institutions in 1 country.

Thomas ReinehrVestische Kinder- und Jugendklinik Datteln, University Witten/Herdecke, Datteln, Germany.
Dirk SchnabelSozialpädiatrisches Zentrum für chronisch kranke Kinder, Charité Universitätsmedizin Berlin, Berlin, Germany. dirk.schnabel@charite.de.
Martin WabitschChildren's Hospital, University of Ulm, Ulm, Germany.
Susanne Bechtold-Dalla PozzaLMU, Ludwig-Maximilians-Universität München, Dr. von Hauner Children's Hospital, Munich, Germany.
Christoph BührerNeonatology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Bettina HeidtmannCatholic Children Hospital Wilhelmstift, Hamburg, Pediatric Endocrinology, Clinic Itzehoe, Hamburg, Germany.
Frank JochumEvangelisches Waldkrankenhaus Berlin Spandau, Berlin, Germany.
Thomas Kauth, Ludwigsburg, Germany.
Antje KörnerDepartment of Women's and Children's Medicine, Paediatric Research Center, University of Leipzig, Leipzig, Germany.
Walter MihatschChildren's Hospital, Heliosklinikum Pforzheim, Pforzheim, Germany.
Christine PrellLMU, Ludwig-Maximilians-Universität München, Dr. von Hauner Children's Hospital, Munich, Germany.
Silvia RudloffInstitute for Nutritional Sciences, University of Giessen, Giessen, Germany.
Bettina TittelChildren's Hospital Dresden-Friedrichstadt, Dresden, Germany.
Joachim WoelfleChildren's Hospital, University of Bonn, Bonn, Germany.
Klaus-Peter ZimmerChildren's Hospital, University of Giessen, Giessen, Germany.
Berthold KoletzkoLMU, Ludwig-Maximilians-Universität München, Dr. von Hauner Children's Hospital, Munich, Germany. info@dgkj.de.
Ludwig-Maximilians-Universität München · DECharité - Universitätsmedizin Berlin · DEUniversity of Giessen · DEKatholisches Kinderkrankenhaus Wilhelmstift · DEKrankenhaus Dresden-Friedrichstadt · DELeipzig University · DESiloah St. Trudpert Klinikum · DEUniversität Ulm · DEUniversity of Bonn · DEVestische Caritas-Kliniken · DEWaldkrankenhaus Protestant Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLow vitamin D serum concentrations have been associated with rickets and other disorders in observational studies. Since vitamin D serum concentrations in children and adolescents are frequently below reference values, it is debated whether vitamin D should be supplemented after infancy.

methodsThe effects of vitamin D supplementation in children > 2 years of age are analyzed based on a literature review of randomized controlled trials (RCTs).

resultsVitamin D supplementation can potentially reduce the risk for influenza infections and improve asthma bronchiale exacerbation; however, it has no impact on asthma bronchiale severity. Vitamin D supplementation has no relevant effect on attention-deficit/hyperactivity disorders, cardiac failure, hypertension, or incidence of type II diabetes mellitus. Vitamin D supplementation has no effect on the rate of multiple sclerosis relapses, but on the number of new lesions detected by MRI. For other endpoints, RCTs are lacking.

conclusionBased on currently available studies, routine vitamin D supplementation is not be recommended for children aged > 2 years, even when they have serum concentrations below reference values. Routine vitamin D supplementation is not recommended in children who do not have risk factors and chronic diseases which are associated with calcium or vitamin D resorption disorders.

Indexed as

Asthma bronchialeAttention-deficit/hyperactivity disorderDiabetes mellitusHypertensionInfectionObesityVitamin D supplementation

Identifiers

PMID31062205
PMCPMC6502918
OpenAlexW2947873048

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.