Evidence map›Paper›PMID 31062189›Full record

Trial reportNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2019

Effects on cognition of 20-day anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex in patients affected by mild cognitive impairment: a case-control study.

Enrico Fileccia, Vitantonio Di Stasi, Roberto Poda, Giovanni Rizzo, Michelangelo Stanzani-Maserati, Federico Oppi, Patrizia Avoni, Sabina Capellari, Rocco Liguori

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05584748 (Effects of Transcranial Direct Current Stimulation), which is not on this map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05584748 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effects of Transcranial Direct Current Stimulation (tDCS) on Cognition in Older Adults With Mild Cognitive Impairment: A Randomized Controlled Trial

TypeinterventionalSponsorTung Wah CollegeRan2023 to 2026Enrolled48ConditionsMild Cognitive ImpairmentArmstranscranial direct current stimulation
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 41 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Enrico FilecciaDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy. enrico.fileccia@studio.unibo.it.ORCID http://orcid.org/0000-0002-3943-7539
Vitantonio Di StasiInstitute of Neurological Sciences of Bologna, Bologna, Italy.
Roberto PodaInstitute of Neurological Sciences of Bologna, Bologna, Italy.
Giovanni RizzoDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Michelangelo Stanzani-MaseratiInstitute of Neurological Sciences of Bologna, Bologna, Italy.
Federico OppiInstitute of Neurological Sciences of Bologna, Bologna, Italy.
Patrizia AvoniDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Sabina CapellariDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Rocco LiguoriDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Institute of Neurological Sciences · ITUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMild cognitive impairment (MCI) is a common disorder affecting as much as 15% of the elderly population. Transcranial direct current stimulation (tDCS) is a non-invasive technique of neuromodulation that has proven to influence performance in different cognitive domains. OBJECTIVE/HYPOTHESIS: We investigated the effects on cognition of 20-day anodal tDCS in 17 MCI patients compared with 17 matched MCI patients.

methodsPatients underwent neuropsychological evaluation at baseline and then were randomly assigned to the anodal or sham group. The tDCS protocol consisted in 20 min, 5 days per week (up to a total of 20 days), of 2-mA anodal stimulation over the left dorsolateral prefrontal cortex (DLPFC). The location of anodal electrode was chosen in accordance with previous reports which relate anodal stimulation of this site with cognitive enhancement. At the end of the last day of stimulation, a second neuropsychological evaluation was performed. We compared baseline and post-stimulation neuropsychological results in the anodal vs sham group using repeated measures ANOVA as a statistical analysis test.

resultsAt follow-up, patients exposed to anodal stimulation showed improvement in episodic verbal memory (p < 0.001) and figure naming test (p < 0.01), in a general index of cognitive function (Brief Mental Deterioration Battery) (p < 0.0001) and in a mood measurement test (Beck Depression Inventory) (p < 0.01).

conclusionAnodal tDCS could be a useful tool to improve cognitive symptoms in MCI although more evidence is needed to understand the exact underlying mechanisms. Confirmation of its potential benefits in MCI would be significant.

Indexed as

Neuropsychological TestsPrefrontal CortexAffectAgedCase-Control StudiesCognitive DysfunctionFemaleFollow-Up StudiesHumansLanguageMaleMemory, EpisodicPattern Recognition, VisualTranscranial Direct Current StimulationTreatment OutcomeCognitionDLPFCMCIMild cognitive impairmentNeuropsychologytDCSTranscranial direct current stimulation

Identifiers

PMID31062189
OpenAlexW2944071401

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.