ArticleSurgical endoscopy2020
Clinical outcomes of upper gastrointestinal bleeding in patients with gastric gastrointestinal stromal tumor.
Article in Surgical endoscopy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Prognostic Value of Bleeding in Gastrointestinal Stromal Tumors: A Meta-Analysis.Technology in cancer research & treatmentPooled it
- Endoscopic Hemostasis for Gastrointestinal Stromal Tumor Hemorrhage: A Case Series and Retrospective Analysis of Risk Factors.DEN open · 2026Article
- Gastric cardiac leiomyoma complicated with massive gastrointestinal bleeding: A rare case report.Medicine · 2025Article
- Efficacy and safety of tranexamic acid in the treatment of gastric cancer complicated with upper gastrointestinal bleeding.American journal of translational research · 2024Article
- The prognostic role of gastrointestinal bleeding in patients with a primary gastrointestinal stromal tumor: a long-term follow-up study.Journal of gastrointestinal oncology · 2023Article
- A novel technique for endoscope progression in gastroscopy resection: forward-return way for dissection of stromal tumor in the muscularis propria of the gastric fundus.Frontiers in oncology · 2023Article
- Laparoscopic subtotal gastrectomy in case of large subcardial GISTs.Journal of surgical case reports · 2022Article
- A Huge Malignant Gastric Gastrointestinal Stromal Tumor in a Young Patient.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2022Article
- Unusual Gastrointestinal Hemorrhaging Mimicking a Rupture of Solitary Gastric Varices Due to a Gastric Gastrointestinal Stromal Tumor with Exogenous Growth.Internal medicine (Tokyo, Japan) · 2022Article
- Th1, Th2, and Th17 cells and their corresponding cytokines are associated with anxiety, depression, and cognitive impairment in elderly gastric cancer patients.Frontiers in surgery · 2022Article
- Clinical outcomes of tumor bleeding in duodenal gastrointestinal stromal tumors: a 20-year single-center experience.Surgical endoscopy · 2021Article
- Endoscopic obturation with tissue adhesive for bleeding gastric stromal tumor: a case report.The Journal of international medical research · 2021Article
- A bleeding GIST in pandemic times, a cooperative approach to a delayed complication, a case report.International journal of surgery case reports · 2020Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUpper gastrointestinal bleeding (UGIB) is one of the major manifestations of gastrointestinal stromal tumor (GIST) of the stomach. Several studies have reported that GIST bleeding is associated with poor prognosis. However, only case reports have reported hemostasis modalities for treating hemorrhagic gastric GIST. To identify clinical outcome of gastric GIST bleeding, we analyzed risk factors and prognosis of hemorrhagic GIST evaluating hemostasis methods.
methodsTotal 697 patients histopathologically diagnosed with primary gastric GIST between January 1998 and May 2015 were enrolled to the study, retrospectively.
resultsOf 697 total patients, 46 (6.6%) patients had UGIB. Endoscopic intervention, transarterial embolization, or surgical intervention was performed for initial hemostasis in 15, 2, and 1, respectively. Over a median of 68 months of follow-up, 16 patients in bleeding group and 88 patients in non-bleeding group died; the 5-year survival rate was 79.4% in bleeding group and 91.8% in non-bleeding group (p = 0.004). Multivariate analysis showed that significant risk factors for gastric GIST bleeding included the maximal tumor diameter > 5 cm and Ki-67 positivity. Age ≥ 60 [hazard ratio (HR) = 8.124, p = 0.048], necrosis (HR = 5.093, p = 0.027), and bleeding (HR 5.743, p = 0.034) were significant factors for overall survival of gastric GIST patients.
conclusionsBleeding risk of gastric GIST was higher when tumor had diameter > 5 cm or Ki-67 positivity. In addition, tumor bleeding, necrosis, and age ≥ 60 years were associated with poor overall survival. Endoscopic intervention can be considered as an effective method for initial hemostasis of hemorrhagic gastric GIST.
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