ArticleIntensive care medicine2019
Mechanical power normalized to predicted body weight as a predictor of mortality in patients with acute respiratory distress syndrome.
Article in Intensive care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 79 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mechanical Power Normalized to Compliance in Patients With Acute Respiratory Distress Syndrome
Assessment of Mechanical Power Components on the Functional Lung in Patients With Acute Respiratory Distress Syndrome (ARDS)
Who cites it
79 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review of machine learning models for management, prediction and classification of ARDS.Respiratory research · 2024Pooled it
- Electrical impedance tomography-guided positive end-expiratory pressure titration in ARDS: a systematic review and meta-analysis.Intensive care medicine · 2024Pooled it
- Mechanical Power and the Association with Postoperative Impaired Oxygenation and Pulmonary Complications in Orthopedic Patients: Post Hoc Analysis of a Cluster Factorial Randomized Trial.Anesthesiology · 2026Trial
- Mechanical power during one-lung ventilation is associated with postoperative pulmonary complications in patients undergoing lobectomy: a single-center prospective cohort study.BMC anesthesiology · 2026Trial
- Protective mechanical ventilation controlled by the real-time mechanical power measurement.Journal of clinical monitoring and computing · 2026Trial
- The effect of bilateral rectus sheath and oblique subcostal transversus abdominis plane blocks on mechanical power in patients undergoing laparoscopic cholecystectomy surgery: a randomized controlled trial.BMC anesthesiology · 2025Trial
- Bedside Assessment of PEEP-Induced Volume and Mechanical Power in Mechanically Ventilated Adults Without ARDS: A Post Hoc Analysis.Medical sciences (Basel, Switzerland) · 2026Article
- Minimum observation time to determine ventilator liberation success and its associated factors in tracheostomized patients in intensive and high-care units in Japan: a single-center retrospective study.Acute and critical care · 2026Article
- The relationship between the chronological phases of diffuse alveolar damage and clinical outcomes in acute respiratory distress syndrome.Journal of intensive care · 2026Article
- Intraoperative mechanical power and postoperative pulmonary complications: association and threshold analysis in adult intra-abdominal surgery.Journal of anesthesia, analgesia and critical care · 2026Article
- Impact of cannula configuration on efficiency and mechanical ventilation intensity during venovenous ECMO.BMC pulmonary medicine · 2026Article
- Association of compliance-normalized airway and transpulmonary mechanical power with mortality in PARDS.European journal of pediatrics · 2026Observational
- The role of mechanical power in lung ventilation for the prevention of ventilator-induced lung injury: a narrative review.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Validation of the Formulas for Mechanical Power in Children and Proposal of the Concept of "Effective Mechanical Power".Journal of clinical medicine · 2026Article
- Correlation of mechanical power and outcome in critically ill patients in Indian population: A prospective observational study.Indian journal of anaesthesia · 2026Article
- Ventilator-induced lung injury: from mechanisms to integrated clinical management.Frontiers in medicine · 2026Review
- Exploring the association of mechanical power with mortality and phenotypes among patients with acute respiratory distress syndrome: a retrospective analysis.Frontiers in medicine · 2026Article
- Trajectory patterns of mechanical power and prognosis in ARDS: a longitudinal analysis using group-based trajectory modeling.European journal of medical research · 2025Article
- Subphenotypes of mechanically ventilated acute respiratory distress syndrome patients based on multi-dimensional pathophysiological parameters.Critical care (London, England) · 2025Observational
- Brain Protective Ventilation Strategies in Severe Acute Brain Injury.Current neurology and neuroscience reports · 2025Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeProtective mechanical ventilation based on multiple ventilator parameters such as tidal volume, plateau pressure, and driving pressure has been widely used in acute respiratory distress syndrome (ARDS). More recently, mechanical power (MP) was found to be associated with mortality. The study aimed to investigate whether MP normalized to predicted body weight (norMP) was superior to other ventilator variables and to prove that the discrimination power cannot be further improved with a sophisticated machine learning method.
methodsThe study included individual patient data from eight randomized controlled trials conducted by the ARDSNet. The data was split 3:1 into training and testing subsamples. The discrimination of each ventilator variable was calculated in the testing subsample using the area under receiver operating characteristic curve. The gradient boosting machine was used to examine whether the discrimination could be further improved.
resultsA total of 5159 patients with acute onset ARDS were included for analysis. The discrimination of norMP in predicting mortality was significantly better than the absolute MP (p = 0.011 for DeLong's test). The gradient boosting machine was not able to improve the discrimination as compared to norMP (p = 0.913 for DeLong's test). The multivariable regression model showed a significant interaction between norMP and ARDS severity (p < 0.05). While the norMP was not significantly associated with mortality outcome (OR 0.99; 95% CI 0.91-1.07; p = 0.862) in patients with mild ARDS, it was associated with increased risk of mortality in moderate (OR 1.11; 95% CI 1.02-1.23; p = 0.021) and severe (OR 1.13; 95% CI 1.03-1.24; p < 0.008) ARDS.
conclusionsThe study showed that norMP was a good ventilator variable associated with mortality, and its predictive discrimination cannot be further improved with a sophisticated machine learning method. Further experimental trials are needed to investigate whether adjusting ventilator variables according to norMP will significantly improve clinical outcomes.
Indexed as
Identifiers
31062050What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.