Evidence map›Paper›PMID 31061923›Full record

ArticleJACC. Basic to translational science2019

Characterization of a Unique Form of Arrhythmic Cardiomyopathy Caused by Recessive Mutation in LEMD2.

Nelly Abdelfatah, Ruping Chen, Henry J Duff, Colette M Seifer, Ilan Buffo, Cathleen Huculak, Stephanie Clarke, Robin Clegg, Davinder S Jassal, Paul M K Gordon and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Understanding inherited cardiomyopathies: clinical aspects and genetic determinants.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Dilated Cardiomyopathy: A Genetic Journey from Past to Future.International journal of molecular sciences · 2024
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. The Many Faces of Arrhythmogenic Cardiomyopathy: An Overview.The application of clinical genetics · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Nelly AbdelfatahDepartment of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Ruping ChenComprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, Germany.
Henry J DuffDepartment of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Colette M SeiferSection of Cardiology, Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Ilan BuffoVariety Children's Heart Centre, University of Manitoba, Winnipeg, Manitoba, Canada.
Cathleen HuculakDepartment of Medical Genetics, Alberta Health Services, Calgary, Alberta, Canada.
Stephanie ClarkeDepartment of Biochemistry and Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Robin CleggDepartment of Pediatrics, University of Calgary, Calgary, Alberta, Canada.
Davinder S JassalSection of Cardiology, Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Paul M K GordonCumming School of Medicine Centre for Health Genomics and Informatics, University of Calgary, Calgary, Alberta, Canada.
Carole OberDepartment of Human Genetics, The University of Chicago, Chicago, Illinois.
Care4Rare Canada Consortium
Patrick FroskDepartment of Biochemistry and Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Brenda GerullDepartment of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
University of Manitoba · CAUniversity of Calgary · CAUniversitätsklinikum Würzburg · DEAlberta Health Services · CALibin Cardiovascular Institute of Alberta · CAUniversity of Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nuclear envelope proteins have been shown to play an important role in the pathogenesis of inherited dilated cardiomyopathy. Here, we present a remarkable cardiac phenotype caused by a homozygous

Indexed as

ACM, arrhythmogenic cardiomyopathyBANF, barrier to autointegration factorchromatin remodelingCMR, cardiac magnetic resonanceDAPI, 4′,6′-diamidino-2-phenylindoleDCM, dilated cardiomyopathydilated cardiomyopathyDNA, deoxyribonucleic acideGFP, enhanced green fluorescent proteinEMD, emerinICD, implantable cardioverter-defibrillatorinner nuclear membraneLEMD2LEMD2, LEM domain containing protein 2LGE, late gadolinium enhancementLMNA, lamin A/CLV, left ventricularNE, nuclear envelopePBS, phosphate-buffered salineP, passageSAHF, senescence-associated heterochromatin fociSNV, single nucleotide variantsudden death

Identifiers

PMID31061923
PMCPMC6488817
OpenAlexW2942609213

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.