Evidence map›Paper›PMID 31061898›Full record

ArticleBiochemistry and biophysics reports2019

Modulation of B cell activation threshold mediated by BCR/CD40 costimulation by targeting Cbl-b for ubiquitination.

Na Tang, Lifen Yang, Dongdong Li, Rushi Liu, Jian Zhang

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Na TangLaboratory of Medical Molecular and Immunological Diagnostics (LMMID), Hunan Normal University, 371 Tongzipo Road, Changsha, Hunan, 410013, PR China.
Lifen YangDepartment of Pediatrics, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, PR China.
Dongdong LiDepartment of Orthopedics, Rush University Medical Center, 1735 West Harrison Street, Chicago, IL, 60612, USA.
Rushi LiuLaboratory of Medical Molecular and Immunological Diagnostics (LMMID), Hunan Normal University, 371 Tongzipo Road, Changsha, Hunan, 410013, PR China.
Jian ZhangDepartment of Orthopedics, Rush University Medical Center, 1735 West Harrison Street, Chicago, IL, 60612, USA.
Rush University Medical Center · USHunan Normal University · CNUniversity of Iowa · USXiangya Hospital Central South University · CN

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
NEDD4 IN T HELPER CELL DEVELOPMENT AND AUTOIMMUNITYR01AI090901 · NIAID · UNIVERSITY OF IOWA · PI WALDSCHMIDT, THOMAS J · 2010 to 2020
$4.0M
Regulation of Innate Immune System Sensing of C. Albicans InfectionsR01AI123253 · NIAID · UNIVERSITY OF IOWA · PI WALDSCHMIDT, THOMAS J · 2016 to 2020
$2.1M
Cbl-b in T Cell Activation and AutoimmunityR01AR049775 · NIAMS · UNIVERSITY OF CHICAGO · PI ZHANG, JIAN · 2004 to 2008
$1.5M
IL-4 Potentiates T Cell Death in Autoimmune ArthritisK02AR049047 · NIAMS · UNIVERSITY OF CHICAGO · PI ZHANG, JIAN · 2002 to 2006
$486k
NIAID NIH HHS R01 AI090901NIAID NIH HHS R01 AI123253NIAMS NIH HHS K02 AR049047NIAMS NIH HHS R01 AR049775
6 · The paper itself

Abstract

It has been shown that CD40 is required for optimal B cell activation. Casitas-B-lineage lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, inhibits B cell activation. In this report, we demonstrate that CD40 stimulation markedly enhances IgM-induced B cell proliferation in wild-type (WT) mice, whereas this cell proliferation was reduced in CD40-deficient (

Identifiers

PMID31061898
PMCPMC6487278
OpenAlexW2941757350

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.