ArticleJGH open : an open access journal of gastroenterology and hepatology2019
High prevalence of non-alcoholic fatty liver disease among healthy male blood donors of urban India.
Article in JGH open : an open access journal of gastroenterology and hepatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease: Mapping Across Different Indian Populations (MAP Study).Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Article
- Effect of exercise and pharmacotherapy on non-alcoholic fatty liver disease.SAGE open medicine · 2024Article
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- The burgeoning cardiovascular disease epidemic in Indians - perspectives on contextual factors and potential solutions.The Lancet regional health. Southeast Asia · 2023Review
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- Work-up for Incidentally Detected NAFLD: How Far is It Worth?Euroasian journal of hepato-gastroenterology · 2022Review
- Nonalcoholic Fatty Liver Disease: Indian Perspective.Clinical liver disease · 2021Review
- Need for hepatitis A prevention in patients with chronic liver disease in the changing epidemiological setting of India.Human vaccines & immunotherapeutics · 2021Article
- High potency multistrain probiotic improves liver histology in non-alcoholic fatty liver disease (NAFLD): a randomised, double-blind, proof of concept study.BMJ open gastroenterology · 2019Article
- FibroScan-AST (FAST) Score for Nonalcoholic Steatohepatitis - Validation in an Indian Cohort.Journal of clinical and experimental hepatologyArticle
- Prevalence and Predictors of Nonalcoholic Fatty Liver Disease in Family Members of Patients With Nonalcoholic Fatty Liver Disease.Journal of clinical and experimental hepatologyArticle
- Prevalence of Non-alcoholic Fatty Liver Disease in India: A Systematic Review and Meta-analysis.Journal of clinical and experimental hepatologyArticle
- Knowledge, Attitude and Practice of Gastroenterologists and Hepatologists Regarding Vaccination in Patients with Chronic Liver Disease.Journal of clinical and experimental hepatologyArticle
- Health-Related Quality of Life Among Liver Disorder Patients in Northern India.Indian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineArticle
- Nonalcoholic Fatty Liver Disease: Role of Medical Colleges in its Prevention and Control.Indian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineArticle
- Lysosomal Acid Lipase Activity in Non-alcoholic Fatty Liver Disease as a Novel Diagnostic and Therapeutic Target: A Systematic Literature Review of Current Evidence and Future Directions.Journal of clinical and experimental hepatologyReview
- Experience With Changing Etiology and Nontransplant Curative Treatment Modalities for Hepatocellular Carcinoma in a Real-Life Setting-A Retrospective Descriptive Analysis.Journal of clinical and experimental hepatologyArticle
- Indian National Association for Study of the Liver (INASL) Guidance Paper on Nomenclature, Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease (NAFLD).Journal of clinical and experimental hepatologyReview
- Lean Fatty Liver Disease: Through Thick and Thin.Journal of clinical and experimental hepatologyArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is limited data on the community prevalence of non-alcoholic fatty liver disease (NAFLD). The present study evaluated the prevalence of NAFLD in a large number of healthy male blood donors of urban north India. METHODOLOGY: In a prospective study performed over 18 months, voluntary blood donors fulfilling the requisite blood donation criteria and consenting to participate in the study were evaluated. The study received the approval of the institute's ethics committee. Diagnosis of NAFLD was made by excluding significant alcohol intake, ultrasound showing hepatic steatosis, and exclusion of transfusion associated infections. Subjects were also evaluated for various metabolic risk factors and the presence of metabolic syndrome.
resultsOf 1388 subjects who consented for participation, 386 did not come for evaluation. Three females, nine (0.9%) HBsAg-positive, and four (0.4%) anti-HCV positive subjects were excluded. Of the 986 males evaluated with hepatobiliary ultrasound, 543(55.1%) had fatty liver on ultrasonography [15 (1.5%) alcoholic fatty liver and 528 (53.5%) NAFLD]. Among those with NAFLD, 469 (88.8%), 54 (10.2%), and 5 (0.9%) had mild, moderate, and severe hepatic steatosis, respectively. Subjects with NAFLD, when compared to those without NAFLD, had significantly higher age, BMI, waist circumference, blood pressure, total cholesterol and triglycerides, low-density lipoprotein, and fasting plasma glucose. Multivariate regression analysis demonstrated age, BMI, waist circumference, systolic blood pressure, total cholesterol, and number of metabolic syndrome criteria as independent predictors of NAFLD.
conclusionsUrban Indian healthy male blood donors have a high prevalence of NAFLD.
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