ArticleScientific reports2019
Average firing rate rather than temporal pattern determines metabolic cost of activity in thalamocortical relay neurons.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Sleep firing rate homeostasis is disrupted in mild parkinsonism.NPJ Parkinson's disease · 2026Article
- Neurobiology of mitochondrial dynamics in sleep.The Journal of physiology · 2025Review
- Circuit-selective pharmacological targeting of prefrontal cortex-projecting locus coeruleus neurons drives antinociception.Cell reports · 2025Article
- A multiscale electro-metabolic model of a rat neocortical circuit reveals the impact of ageing on central cortical layers.PLoS computational biology · 2025Article
- Recurrent neural networks with transient trajectory explain working memory encoding mechanisms.Communications biology · 2025Article
- Divisive normalization is an efficient code for multivariate Pareto-distributed environments.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- High Iron and Iron Household Protein Contents in Perineuronal Net-Ensheathed Neurons Ensure Energy Metabolism with Safe Iron Handling.International journal of molecular sciences · 2022Article
- Metabolic tuning of inhibition regulates hippocampal neurogenesis in the adult brain.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Mice Preferentially Use Increases in Cerebral Cortex Spiking to Detect Changes in Visual Stimuli.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Metabolic Cost of Dendritic CaFrontiers in neuroscience · 2019Article
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Authors and funding
2 authors.
Funding
Abstract
Thalamocortical (TC) relay cells exhibit different temporal patterns of activity, including tonic mode and burst mode, to transmit sensory information to the cortex. Our aim was to quantify the metabolic cost of different temporal patterns of neural activity across a range of average firing rates. We used a biophysically-realistic model of a TC relay neuron to simulate tonic and burst patterns of firing. We calculated the metabolic cost by converting the calculated ion fluxes into the demand for ATP to maintain homeostasis of intracellular ion concentrations. Most energy was expended on reversing Na
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