ArticleScientific reports2019
DNA Length-dependent Division of a Giant Vesicle-based Model Protocell.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Orchestrating Self-Replication in Artificial Cells with Digital Microfluidics.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Peptide-Induced Division of Polymersomes for Biomimetic Compartmentalization.Angewandte Chemie (International ed. in English) · 2024Article
- Protocell Effects on RNA Folding, Function, and Evolution.Accounts of chemical research · 2024Article
- Evolution of Proliferative Model Protocells Highly Responsive to the Environment.Life (Basel, Switzerland) · 2022Review
- Colocalization Analysis of Lipo-Deoxyribozyme Consisting of DNA and Protic Catalysts in a Vesicle-Based Protocellular Membrane Investigated by Confocal Microscopy.Life (Basel, Switzerland) · 2021Article
- Synthesis of lipid membranes for artificial cells.Nature reviews. Chemistry · 2021Review
- Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life.Nature communications · 2021Article
- Increasing complexity of primitive compartments.Biophysics and physicobiology · 2021Article
- Modularize and Unite: Toward Creating a Functional Artificial Cell.Frontiers in molecular biosciences · 2021Review
- Self-Emergent Protocells Generated in an Aqueous Solution with Binary Macromolecules through Liquid-Liquid Phase Separation.Chembiochem : a European journal of chemical biology · 2020Article
- Chemical Analysis of Lipid Boundaries after Consecutive Growth and Division of Supported Giant Vesicles.iScience · 2020Article
- Environment-Sensitive Intelligent Self-Reproducing Artificial Cell with a Modification-Active Lipo-Deoxyribozyme.Micromachines · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA is an essential carrier of sequence-based genetic information for all life today. However, the chemical and physical properties of DNA may also affect the structure and dynamics of a vesicle-based model protocell in which it is encapsulated. To test these effects, we constructed a polyethylene glycol-grafted giant vesicle system capable of undergoing growth and division. The system incorporates a specific interaction between DNA and lipophilic catalysts as well as components of PCR. We found that vesicle division depends on the length of the encapsulated DNA, and the self-assembly of an internal supramolecular catalyst possibly leads to the direct causal relationship between DNA length and the capacity of the vesicle to self-reproduce. These results may help elucidate how nucleic acids could have functioned in the division of prebiotic protocells.
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