ArticleScientific reports2019
Blueprint for nanoscale NMR.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Robust parahydrogen-induced polarization at high concentrations.Science advances · 2024Article
- Mapping a 50-spin-qubit network through correlated sensing.Nature communications · 2024Article
- Quantum sensors for biomedical applications.Nature reviews. Physics · 2023Review
- Advances in nano- and microscale NMR spectroscopy using diamond quantum sensors.Chemical communications (Cambridge, England) · 2022Review
- Paramagnetic encoding of molecules.Nature communications · 2022Article
- Parallel detection and spatial mapping of large nuclear spin clusters.Nature communications · 2022Article
- Sequential Bayesian experiment design for optically detected magnetic resonance of nitrogen-vacancy centers.Physical review applied · 2020Article
- High Temperature Treatment of Diamond Particles Toward Enhancement of Their Quantum Properties.Frontiers in physics · 2020Article
- Ultrasensitive Magnetic Field Sensors for Biomedical Applications.Sensors (Basel, Switzerland) · 2020Review
- Robust optical polarization of nuclear spin baths using Hamiltonian engineering of nitrogen-vacancy center quantum dynamics.Science advances · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitrogen vacancy (NV) centers in diamond have been used as ultrasensitive magnetometers to perform nuclear magnetic resonance (NMR) spectroscopy of statistically polarized samples at 1-100 nm length scales. However, the spectral linewidth is typically limited to the kHz level, both by the NV sensor coherence time and by rapid molecular diffusion of the nuclei through the detection volume which in turn is critical for achieving long nuclear coherence times. Here we provide a blueprint supported by detailed theoretical analysis for a set-up that combines a sensitivity sufficient for detecting NMR signals from nano- to micron-scale samples with a spectral resolution that is limited only by the nuclear spin coherence, i.e. comparable to conventional NMR. Our protocol detects the nuclear polarization induced along the direction of an external magnetic field with near surface NV centers using lock-in detection techniques to enable phase coherent signal averaging. Using the NV centers in a dual role of NMR detector and optical hyperpolarization source to increase signal to noise, and in combination with Bayesian inference models for signal processing, nano/microscale NMR spectroscopy can be performed on sample concentrations in the micromolar range, several orders of magnitude better than the current state of the art.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.