ArticleScientific reports2019
A rat model of complete atrioventricular block recapitulates clinical indices of bradycardia and provides a platform to test disease-modifying therapies.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- AAV-mediated long-term TBX18 expression causes cardiac fibrosis and fails to induce pacemaker activity in rodents.The Journal of clinical investigation · 2026Article
- Preparation of a chronic complete atrioventricular block rat model using myocardial surface radiofrequency ablation.Frontiers in pharmacology · 2026Article
- A highly effective, rodent model of complete heart block by epicardial radiofrequency ablation.Scientific reports · 2025Article
- Transient pacing in pigs with complete heart block via myocardial injection of mRNA coding for the T-box transcription factor 18.Nature biomedical engineering · 2024Article
- New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models.Scientific reports · 2023Article
- Harnessing cell reprogramming for cardiac biological pacing.Journal of biomedical science · 2023Review
- Animal Models to Study Cardiac Arrhythmias.Circulation research · 2022Review
- Cellular regeneration as a potential strategy to treat cardiac conduction disorders.The Journal of clinical investigation · 2021Article
- Regeneration of infarcted mouse hearts by cardiovascular tissue formed via the direct reprogramming of mouse fibroblasts.Nature biomedical engineering · 2021Article
- Development and optimization of an in vivo electrocardiogram recording method and analysis program for adult zebrafish.Disease models & mechanisms · 2021Article
- Cellular Reprogramming Approaches to Engineer Cardiac Pacemakers.Current cardiology reports · 2020Review
- Development of a sheep model of atrioventricular block for the application of novel therapies.PloS one · 2020Article
- Engineered Cardiac Pacemaker Nodes Created by TBX18 Gene Transfer Overcome Source-Sink Mismatch.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Induced cardiac pacemaker cells survive metabolic stress owing to their low metabolic demand.Experimental & molecular medicine · 2019Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Complete atrioventricular block (CAVB) is a life-threatening arrhythmia. A small animal model of chronic CAVB that properly reflects clinical indices of bradycardia would accelerate the understanding of disease progression and pathophysiology, and the development of therapeutic strategies. We sought to develop a surgical model of CAVB in adult rats, which could recapitulate structural remodeling and arrhythmogenicity expected in chronic CAVB. Upon right thoracotomy, we delivered electrosurgical energy subepicardially via a thin needle into the atrioventricular node (AVN) region of adult rats to create complete AV block. The chronic CAVB animals developed dilated and hypertrophied ventricles with preserved systolic functions due to compensatory hemodynamic remodeling. Ventricular tachyarrhythmias, which are difficult to induce in the healthy rodent heart, could be induced upon programmed electrical stimulation in chronic CAVB rats and worsened when combined with β-adrenergic stimulation. Focal somatic gene transfer of TBX18 to the left ventricular apex in the CAVB rats resulted in ectopic ventricular beats within days, achieving a de novo ventricular rate faster than the slow atrioventricular (AV) junctional escape rhythm observed in control CAVB animals. The model offers new opportunities to test therapeutic approaches to treat chronic and severe CAVB which have previously only been testable in large animal models.
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