ArticleScientific reports2019
Inferring the direction of rhythmic neural transmission via inter-regional phase-amplitude coupling (ir-PAC).
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- Boosting hemianopia recovery: the power of interareal cross-frequency brain stimulation.Brain : a journal of neurology · 2025Trial
- I Can't Hear You Both at the Same Time: A Temporal Dilemma During Inter-Regional Communication.eNeuro · 2026Article
- A pilot study of inter-regional phase amplitude coupling as comorbid depression biomarker in temporal lobe epilepsy.Epilepsy & behavior : E&B · 2025Article
- CB-1 receptor agonist drastically changes oscillatory activity, defining active sleep.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Differential neural mechanisms underlie cortical gating of visual spatial attention mediated by alpha-band oscillations.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Neural decoding and feature selection methods for closed-loop control of avoidance behavior.Journal of neural engineering · 2024Article
- Dynamic evolution of frontal-temporal network connectivity in temporal lobe epilepsy: A magnetoencephalography study.Human brain mapping · 2024Article
- Mouse Escape Behaviors and mPFC-BLA Activity Dataset: Understanding Flexible Defensive Strategies Under Threat.Scientific data · 2024Article
- Neural Decoding and Feature Selection Techniques for Closed-Loop Control of Defensive Behavior.bioRxiv : the preprint server for biology · 2024Article
- Dopamine D4 Receptor Agonist Drastically Increases Delta Activity in the Thalamic Nucleus Reuniens: Potential Role in Communication between Prefrontal Cortex and Hippocampus.International journal of molecular sciences · 2023Article
- Respiration organizes gamma synchrony in the prefronto-thalamic network.Scientific reports · 2023Article
- Toward the Identification of Neurophysiological Biomarkers for Alzheimer's Disease in Down Syndrome: A Potential Role for Cross-Frequency Phase-Amplitude Coupling Analysis.Aging and disease · 2023Review
- Face-induced gamma oscillations and event-related potentials in patients with epilepsy: an intracranial EEG study.BMC neuroscience · 2022Article
- Respiratory coupling between prefrontal cortex and hippocampus of rats anaesthetized with urethane in theta and non-theta states.The European journal of neuroscience · 2021Article
- Delta-range coupling between prefrontal cortex and hippocampus supported by respiratory rhythmic input from the olfactory bulb in freely behaving rats.Scientific reports · 2021Article
- Dissociating harmonic and non-harmonic phase-amplitude coupling in the human brain.NeuroImage · 2021Article
- Lack of redundancy between electrophysiological measures of long-range neuronal communication.BMC biology · 2021Article
- Delta-range coupling between prefrontal cortex and hippocampus supported by respiratory rhythmic input from the olfactory bulb in freely behaving rats.bioRxiv : the preprint server for biology · 2021Article
- Revealing the Dynamic Nature of Amplitude Modulated Neural Entrainment With Holo-Hilbert Spectral Analysis.Frontiers in neuroscience · 2021Article
- Neuromodulation of Hippocampal-Prefrontal Cortical Synaptic Plasticity and Functional Connectivity: Implications for Neuropsychiatric Disorders.Frontiers in cellular neuroscience · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Phase-amplitude coupling (PAC) estimates the statistical dependence between the phase of a low-frequency component and the amplitude of a high-frequency component of local field potentials (LFP). To date PAC has been mainly applied to one signal. In this work, we introduce a new application of PAC to two LFPs and suggest that it can be used to infer the direction and strength of rhythmic neural transmission between distinct brain networks. This hypothesis is based on the accumulating evidence that transmembrane currents related to action potentials contribute a broad-band component to LFP in the high-gamma band, and PAC calculated between the amplitude of high-gamma (>60 Hz) in one LFP and the phase of a low-frequency oscillation (e.g., theta) in another would therefore relate the output (spiking) of one area to the input (somatic/dendritic postsynaptic potentials) of the other. We tested the hypothesis on theta-band long range communications between hippocampus and prefrontal cortex (PFC) and theta-band short range communications between dentate gyrus (DG) and the Ammon's horn (CA1) within the hippocampus. The ground truth was provided by the known anatomical connections predicting hippocampus → PFC and DG → CA1, i.e., theta transmission is unidirectional in both cases: from hippocampus to PFC and from DG to CA1 along the tri-synaptic pathway within hippocampus. We found that (1) hippocampal high-gamma amplitude was significantly coupled to PFC theta phase, but not vice versa; (2) similarly, DG high-gamma amplitude was significantly coupled to CA1 theta phase, but not vice versa, and (3) the DG high-gamma-CA1 theta PAC was significantly correlated with DG → CA1 Granger causality, a well-established analytical measure of directional neural transmission. These results support the hypothesis that inter-regional PAC (ir-PAC) can be used to relate the output of a rhythmic "driver" network (i.e., high gamma) to the input of a rhythmic "receiver" network (i.e., theta) and thereby establish the direction and strength of rhythmic neural transmission.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.