Evidence map›Paper›PMID 31061173›Full record

ArticleThe EMBO journal2019

Anoctamin 8 tethers endoplasmic reticulum and plasma membrane for assembly of Ca

Archana Jha, Woo Young Chung, Laura Vachel, Jozsef Maleth, Sarah Lake, Guofeng Zhang, Malini Ahuja, Shmuel Muallem

Open access · greenAbstract read
In one paragraph

Article in The EMBO journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.

  1. Stay in touch with the endoplasmic reticulum.Science China. Life sciences · 2024
    Pooled it
  2. Article
  3. Review
  4. A membrane insertion code for intrinsically disordered proteins.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. TMEM16 proteins: CaInternational journal of molecular medicine · 2024
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Archana JhaThe Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Woo Young ChungThe Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Laura VachelThe Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Jozsef MalethFirst Department of Medicine, University of Szeged, Szeged, Hungary.ORCID 0000-0001-5768-3090
Sarah LakeThe Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Guofeng ZhangTrans-NIH Shared Resource on Biomedical Engineering and Physical Science (BEPS) National Institute of Biomedical Imaging & Bioengineering, Bethesda, MD, USA.
Malini AhujaThe Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Shmuel MuallemThe Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA shmuel.muallem@nih.gov.ORCID 0000-0002-6189-4947
National Institutes of Health · USNational Institute of Biomedical Imaging and Bioengineering · USUniversity of Szeged · HU

Funding

Ca2+ signaling and HCO3- secretion by exocrine glandsZIADE000735 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI MUALLEM, SHMUEL · 2010 to 2025
$43.1M
6 · The paper itself

Abstract

Communication and material transfer between membranes and organelles take place at membrane contact sites (MCSs). MCSs between the ER and PM, the ER/PM junctions, are the sites where the ER Ca

Indexed as

AnoctaminsCalciumCalcium ChannelsCalcium SignalingCell MembraneEndoplasmic ReticulumHEK293 CellsHeLa CellsHumansMultiprotein ComplexesNeoplasm ProteinsORAI1 ProteinProtein BindingProtein MultimerizationStromal Interaction Molecule 1ANO8 protein, humanAnoctaminsCalciumCalcium ChannelsMultiprotein ComplexesNeoplasm ProteinsORAI1 ProteinSTIM1 protein, humanStromal Interaction Molecule 1ANO8assemblyCa2+signalingtether

Identifiers

PMID31061173
PMCPMC6576175
OpenAlexW2943200412

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.