ArticleEMBO reports2019
Posttranscriptional regulation of colonic epithelial repair by RNA binding protein IMP1/IGF2BP1.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in EMBO reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- The RNA-binding protein Imp1 promotes a Spdef transcriptional program and mucus fucosylation during necrotizing enterocolitis.American journal of physiology. Gastrointestinal and liver physiology · 2026Article
- The key m6A methylation regulator IGF2BP1 possesses potential prognostic value in papillary thyroid carcinoma.Scientific reports · 2026Article
- The RNA-binding protein Imp1 promotes a Spdef transcriptional program and mucus fucosylation during necrotizing enterocolitis.bioRxiv : the preprint server for biology · 2026Article
- Marked for Success: How RNA mCellular and molecular gastroenterology and hepatology · 2026Review
- IMPlications of IMP2 in RNA Biology and Disease.International journal of molecular sciences · 2025Review
- Nurturing gut health: role of m6A RNA methylation in upholding the intestinal barrier.Cell death discovery · 2024Review
- Exploring the impact of mFrontiers in immunology · 2024Review
- Intestinal transit-amplifying cells require METTL3 for growth factor signaling and cell survival.JCI insight · 2023Article
- Intestinal epithelial autophagy is required for the regenerative benefit of calorie restriction.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Spatial transcriptomics add a new dimension to our understanding of the gut.American journal of physiology. Gastrointestinal and liver physiology · 2023Review
- Autophagy in intestinal fibrosis: relevance in inflammatory bowel disease.Frontiers in pharmacology · 2023Review
- IMP1/IGF2BP1 in human colorectal cancer extracellular vesicles.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- A novel peptide encoded by N6-methyladenosine modified circMAP3K4 prevents apoptosis in hepatocellular carcinoma.Molecular cancer · 2022Article
- Article
- Article
- mTOR-autophagy promotes pulmonary senescence through IMP1 in chronic toxicity of methamphetamine.Journal of cellular and molecular medicine · 2020Article
- The mRNA-binding protein IGF2BP1 maintains intestinal barrier function by up-regulating occludin expression.The Journal of biological chemistry · 2020Article
- Roles for Autophagy in Esophageal Carcinogenesis: Implications for Improving Patient Outcomes.Cancers · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
20 authors at 9 institutions in 3 countries.
Priya ChatterjiDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Patrick A WilliamsDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Kelly A WhelanDepartment of Pathology & Laboratory Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Fernando C SamperCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID 0000-0002-7270-7000
Sarah F AndresDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Lauren A SimonDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Louis R ParhamDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Rei MizunoDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Emma T LundsmithThomas Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
David Sm LeeGenomics and Computational Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Shun LiangDepartment of Genetics, Rutgers University, New Brunswick, NJ, USA.
Hr Sagara WijeratneDepartment of Genetics, Rutgers University, New Brunswick, NJ, USA.
Stefanie MartiFels Institute for Cancer Research & Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Lillian ChauDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Veronique GirouxDepartment of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, QC, Canada.
Benjamin J WilkinsDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Gary D WuDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Premal ShahDepartment of Genetics, Rutgers University, New Brunswick, NJ, USA.ORCID 0000-0002-8424-4218
Gian G TartagliaCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID 0000-0001-7524-6310
Kathryn E HamiltonDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA hamiltonk1@email.chop.edu.ORCID 0000-0001-9575-2499
University of Pennsylvania · USChildren's Hospital of Philadelphia · USRutgers, The State University of New Jersey · USCentre for Genomic Regulation · ESInstitució Catalana de Recerca i Estudis Avançats · ESTemple University · USThomas Jefferson University · USUniversitat Pompeu Fabra · ESUniversité de Sherbrooke · CA
Funding
Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4MTRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI REBECCA G WELLS · 1997 to 2026
$32.5MPREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008216 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI EPSTEIN, DOUGLAS J · 1987 to 2023
$8.3MThe LIN28b-Let7-IMP1 axis in colonic epithelial biologyR01DK056645 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI RUSTGI, ANIL K · 2000 to 2021
$6.8MTraining In Tumor VirologyT32CA115299 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ROBERTSON, ERLE S. · 2006 to 2021
$4.7MDynamics and evolution of translational regulationR35GM124976 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI SHAH, PREMAL R · 2017 to 2021
$1.9MHost-microbial interactions in the gut oxygen equilibriumR01GM103591 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI WU, GARY D. · 2013 to 2016
$1.3MRole of Cirhin/Utp4 in biliary development and diseaseK08DK099379 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI WILKINS, BENJAMIN J · 2014 to 2018
$737kThe functional role of mitophagy in esophageal cell biologyK01DK103953 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI WHELAN, KELLY A · 2015 to 2019
$637kThe role of IMP1 mRNA binding protein in intestinal epithelial biologyK01DK100485 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI HAMILTON, KATHRYN ELIZABETH · 2014 to 2018
$631kAutophagy regulation of esophageal basal cell dynamicsR03DK118304 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI WHELAN, KELLY A · 2018 to 2019
$238kIMP1 REGULATION OF AUTOPHAGY IN THE INTESTINAL EPITHELIUMR03DK114463 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI HAMILTON, KATHRYN ELIZABETH · 2017 to 2018
$156kNCATS NIH HHS UL1 TR001878NCI NIH HHS T32 CA115299NIDDK NIH HHS F32 DK093207NIDDK NIH HHS F32 DK107052NIDDK NIH HHS K01 DK100485NIDDK NIH HHS K01 DK103953NIDDK NIH HHS K08 DK099379NIDDK NIH HHS P30 DK050306NIDDK NIH HHS R01 DK056645NIDDK NIH HHS R03 DK114463NIDDK NIH HHS R03 DK118304NIGMS NIH HHS R01 GM103591NIGMS NIH HHS R35 GM124976NIGMS NIH HHS T32 GM008216
Abstract
RNA binding proteins, including IMP1/IGF2BP1, are essential regulators of intestinal development and cancer.
Indexed as
AdultAgedAnimalsAutophagyAutophagy-Related Protein 7BiomarkersCase-Control StudiesCell LineColitis, UlcerativeColonCrohn DiseaseDisease Models, AnimalFemaleGene DeletionGene Expression RegulationGenetic Predisposition to DiseaseAutophagy-Related Protein 7BiomarkersIGF2BP1 protein, humanRNA-Binding ProteinsRNA, Messengercolonic repairIGF2BP1IMP1inflammatory bowel diseaseRNA binding protein
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.