Evidence map›Paper›PMID 31061146›Full record

ReviewJournal of immunology (Baltimore, Md. : 1950)2019

The Neuroimmune Axis in Skin Sensation, Inflammation, and Immunity.

Anna M Trier, Madison R Mack, Brian S Kim

Abstract readReview
In one paragraph

Review in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Review
  2. Article
  3. Skin pain in pediatric atopic dermatitis: mechanisms and management.Current opinion in allergy and clinical immunology · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Type 2 Inflammation and Its Role in Dermatologic Diseases.International journal of dermatology · 2025
    Review
  13. Review
  14. The peripheral neuroimmune system.Journal of leukocyte biology · 2024
    Review
  15. Peripheral CaeNeuro · 2024
    Article
  16. Peripheral CabioRxiv : the preprint server for biology · 2024
    Article
  17. Interleukin-1α links peripheral CaScientific reports · 2024
    Article
  18. Interleukin-1α links peripheral CabioRxiv : the preprint server for biology · 2024
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anna M TrierCenter for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110.
Madison R MackCenter for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0003-2812-0349
Brian S KimCenter for the Study of Itch, Washington University School of Medicine, St. Louis, MO 63110; briankim@wustl.edu.

Funding

TRAINING PROGRAM IN IMMUNOLOGY AND IMMUNOGENETICST32AI007163 · NIAID · WASHINGTON UNIVERSITY · PI Kenneth M Murphy, Kodi S Ravichandran · 1985 to 2026
$14.8M
Neuroimmune Regulation of Atopic DermatitisR01AR070116 · NIAMS · WASHINGTON UNIVERSITY · PI KIM, BRIAN · 2016 to 2021
$3.8M
Innate Immune Regulation of Skin InflammationK08AR065577 · NIAMS · WASHINGTON UNIVERSITY · PI KIM, BRIAN · 2014 to 2018
$711k
NIAID NIH HHS T32 AI007163NIAMS NIH HHS K08 AR065577NIAMS NIH HHS R01 AR070116
6 · The paper itself

Abstract

Although connections between the immune and nervous systems have long been recognized, the precise mechanisms that underlie this relationship are just starting to be elucidated. Advances in sensory biology have unveiled novel mechanisms by which inflammatory cytokines promote itch and pain sensations to coordinate host-protective behavioral responses. Conversely, new evidence has emphasized the importance of immune cell regulation by sensory neurons. By focusing on itch biology and how it has been informed by the more established field of pain research, we highlight recent interdisciplinary studies that demonstrate how novel neuroimmune interactions underlie a diversity of sensory, inflammatory, and infectious diseases.

Indexed as

NeuroimmunomodulationPain PerceptionAnimalsHumansInfectionsInflammationPruritusSensory Receptor CellsSkin

Identifiers

PMID31061146
PMCPMC6563610

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.