Evidence map›Paper›PMID 31061143›Full record

ArticleInfection and immunity2019

Interleukin 1 Receptor-Like 1 (IL1RL1) Promotes Airway Bacterial and Viral Infection and Inflammation.

Niccolette Schaunaman, Amelia Sanchez, Kris Genelyn Dimasuay, Nicole Pavelka, Mari Numata, Rafeul Alam, Richard J Martin, Hong Wei Chu

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Host immune dysfunction and Mycoplasma pneumoniae immune evasion: dual drivers of pathogenesis in Mycoplasma pneumoniae pneumonia.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Niccolette Schaunaman *National Jewish Health, Denver, Colorado, USA.
Amelia Sanchez *University of Colorado Denver, Aurora, Colorado, USA.
Kris Genelyn DimasuayNational Jewish Health, Denver, Colorado, USA.
Nicole PavelkaNational Jewish Health, Denver, Colorado, USA.
Mari NumataNational Jewish Health, Denver, Colorado, USA.
Rafeul AlamNational Jewish Health, Denver, Colorado, USA.
Richard J MartinNational Jewish Health, Denver, Colorado, USA martinr@njhealth.org chuhw@njhealth.org.
Hong Wei ChuNational Jewish Health, Denver, Colorado, USA martinr@njhealth.org chuhw@njhealth.org.
University of Colorado Denver · USNational Jewish Health · US

Funding

Tollip inhibits IL-33 signaling during airway influenza virus infectionU19AI125357 · NIAID · UNIVERSITY OF ARIZONA · PI KRAFT, MONICA · 2016 to 2025
$14.7M
Transcriptomic and Genetic Endotyping of Exacerbation-Prone AsthmaticsP01HL132821 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A · 2017 to 2021
$9.0M
Steroid resistance of airway ILC2sR01AI137970 · NIAID · NATIONAL JEWISH HEALTH · PI ALAM, RAFEUL · 2018 to 2022
$2.3M
IRAK-M in lung defense against rhinovirus infectionR01AI106287 · NIAID · NATIONAL JEWISH HEALTH · PI CHU, HONG W, LI, LIWU · 2014 to 2018
$2.0M
SPLUNC1 in Severe AsthmaR01HL125128 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHU, HONG W, DI, YUANPU PETER · 2015 to 2018
$1.9M
Airway Th2Th17 Cells in Refractory AsthmaR01HL126895 · NHLBI · NATIONAL JEWISH HEALTH · PI ALAM, RAFEUL · 2016 to 2019
$1.8M
Novel function of MUC18: amplification of inflammation in allergic lungsR01HL122321 · NHLBI · NATIONAL JEWISH HEALTH · PI CHU, HONG W · 2015 to 2018
$1.6M
Sprouty-2 Regulation of Signaling in AsthmaR01AI102943 · NIAID · NATIONAL JEWISH HEALTH · PI ALAM, RAFEUL · 2014 to 2017
$1.6M
NHLBI NIH HHS P01 HL132821NHLBI NIH HHS R01 HL122321NHLBI NIH HHS R01 HL125128NHLBI NIH HHS R01 HL126895NIAID NIH HHS R01 AI102943NIAID NIH HHS R01 AI106287NIAID NIH HHS R01 AI137970NIAID NIH HHS U19 AI125357
6 · The paper itself

Abstract

Interleukin 1 receptor-like 1 (IL1RL1), also known as suppression of tumorigenicity 2 (ST2), is the receptor for interleukin 33 (IL-33) and has been increasingly studied in type 2 inflammation. An increase in airway IL-33/ST2 signaling in asthma has been associated with eosinophilic inflammation, but little is known about the role of ST2 in neutrophilic inflammation. Airway

Indexed as

AnimalsBronchoalveolar Lavage FluidEnterovirusEnterovirus InfectionsEpithelial CellsHumansInterleukin-1 Receptor-Like 1 ProteinInterleukin-33Interleukin-8MiceMice, Inbred BALB CMycoplasma pneumoniaePneumonia, MycoplasmaRespiratory SystemIL1RL1 protein, humanIl1rl1 protein, mouseInterleukin-1 Receptor-Like 1 ProteinInterleukin-33Interleukin-8IL1Rl1infectionMycoplasmaneutrophilsrhinovirusST2

Identifiers

PMID31061143
PMCPMC6589056
OpenAlexW2942614661

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.