Evidence map›Paper›PMID 31061140›Full record

ArticleMolecular & cellular proteomics : MCP2019

Proteomic Profiling of Human Prostate Cancer-associated Fibroblasts (CAF) Reveals LOXL2-dependent Regulation of the Tumor Microenvironment.

Elizabeth V Nguyen, Brooke A Pereira, Mitchell G Lawrence, Xiuquan Ma, Richard J Rebello, Howard Chan, Birunthi Niranjan, Yunjian Wu, Stuart Ellem, Xiaoqing Guan and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.

  1. Pooled it
  2. Metabolic convergence of diabetes and prostate cancer: from dysglycemia to tumor microenvironment reprogramming.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
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  9. Neuroendocrine prostate cancer (NEPC)-associatedCancer pathogenesis and therapy · 2026
    Article
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 3 countries.

Elizabeth V NguyenFrom the ‡Cancer Program, Biomedicine Discovery Institute,; Departments of §Biochemistry and Molecular Biology.
Brooke A PereiraFrom the ‡Cancer Program, Biomedicine Discovery Institute,; ¶Anatomy and Developmental Biology, and.
Mitchell G LawrenceFrom the ‡Cancer Program, Biomedicine Discovery Institute,; ¶Anatomy and Developmental Biology, and; ‖Cancer Research Division, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Parkville, Australia.
Xiuquan MaFrom the ‡Cancer Program, Biomedicine Discovery Institute,; Departments of §Biochemistry and Molecular Biology.
Richard J RebelloFrom the ‡Cancer Program, Biomedicine Discovery Institute,; ¶Anatomy and Developmental Biology, and; ‖Cancer Research Division, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Parkville, Australia.
Howard ChanFrom the ‡Cancer Program, Biomedicine Discovery Institute,; Departments of §Biochemistry and Molecular Biology.
Birunthi NiranjanFrom the ‡Cancer Program, Biomedicine Discovery Institute,; ¶Anatomy and Developmental Biology, and.
Yunjian WuFrom the ‡Cancer Program, Biomedicine Discovery Institute,; Departments of §Biochemistry and Molecular Biology.
Stuart EllemFrom the ‡Cancer Program, Biomedicine Discovery Institute,; ¶Anatomy and Developmental Biology, and; **School of Health and Wellbeing, University of Southern Queensland, Ipswich, Queensland, Australia.
Xiaoqing Guan‡‡Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Center for Cancer Bioinformatics, Peking University Cancer Hospital & Institute, Beijing, China.
Jianmin Wu‡‡Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Center for Cancer Bioinformatics, Peking University Cancer Hospital & Institute, Beijing, China.
Joanna N Skhinas§§The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, Australia.
Thomas R Cox§§The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, Australia;; ¶¶St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia.
Gail P RisbridgerFrom the ‡Cancer Program, Biomedicine Discovery Institute,; ¶Anatomy and Developmental Biology, and; ‖Cancer Research Division, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Parkville, Australia;; ‖‖Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia.
Renea A TaylorFrom the ‡Cancer Program, Biomedicine Discovery Institute,; ‖Cancer Research Division, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Parkville, Australia;; ‡‡‡Physiology, Monash University, Clayton, Australia.
Natalie L ListerFrom the ‡Cancer Program, Biomedicine Discovery Institute,; ¶Anatomy and Developmental Biology, and.
Roger J DalyFrom the ‡Cancer Program, Biomedicine Discovery Institute,; Departments of §Biochemistry and Molecular Biology,. Electronic address: roger.daly@monash.edu.
Discovery Institute · USPeking University · CNGarvan Institute of Medical Research · AUPeter MacCallum Cancer Centre · AUSt Vincent's Clinic · AUUniversity of Southern Queensland · AUVictorian Comprehensive Cancer Centre · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In prostate cancer, cancer-associated fibroblasts (CAF) exhibit contrasting biological properties to non-malignant prostate fibroblasts (NPF) and promote tumorigenesis. Resolving intercellular signaling pathways between CAF and prostate tumor epithelium may offer novel opportunities for research translation. To this end, the proteome and phosphoproteome of four pairs of patient-matched CAF and NPF were characterized to identify discriminating proteomic signatures. Samples were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) with a hyper reaction monitoring data-independent acquisition (HRM-DIA) workflow. Proteins that exhibited a significant increase in CAF

Indexed as

ProteomicsTumor MicroenvironmentAmino Acid OxidoreductasesAutocrine CommunicationCancer-Associated FibroblastsCell Line, TumorCell MovementEpithelial CellsExtracellular MatrixHumansMaleNeoplasm ProteinsParacrine CommunicationPhosphoproteinsPhosphorylationProstateAmino Acid OxidoreductasesLOXL2 protein, humanNeoplasm ProteinsPhosphoproteinsProteomeCancer-associated fibroblastsCancer biomarker(s)FibroblastsLOXL2Non-malignant prostate fibroblastsPhosphoproteomeProstate cancerProstate cancer biomarkersTumor microenvironment*

Identifiers

PMID31061140
PMCPMC6601211
OpenAlexW2944168058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.