ArticleProceedings of the National Academy of Sciences of the United States of America2019
Chemical disarming of isoniazid resistance in
Open access · bronzeAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 59 citations in OpenAlex.
- Exploiting DprE2 pathway redundancy to enhance potency and overcome resistance to pretomanid in Mycobacterium tuberculosis.npj antimicrobials and resistance · 2026Article
- Systems-level characterization of EGFR kinase inhibitors reveals heterogeneous effects on Mtb-macrophage interactions.bioRxiv : the preprint server for biology · 2025Article
- Metabolic rewiring of isoniazid sensitivity inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Photoredox-Catalyzed Radical Coupling of C7-Chloromethyl-Substituted Thiazolino Ring-Fused 2-Pyridones with Quinoxalinones.The Journal of organic chemistry · 2024Article
- Mycobacterial Biofilm: Mechanisms, Clinical Problems, and Treatments.International journal of molecular sciences · 2024Review
- TargetingMicrobiology (Reading, England) · 2024Review
- Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug-resistantmBio · 2024Article
- TheMicrobiology spectrum · 2024Article
- Gallein and isoniazid act synergistically to attenuatebioRxiv : the preprint server for biology · 2024Article
- Gallein potentiates isoniazid's ability to suppressFrontiers in microbiology · 2024Article
- Rv1255c, a dormancy-related transcriptional regulator of TetR family in Mycobacterium tuberculosis, enhances isoniazid tolerance in Mycobacterium smegmatis.The Journal of antibiotics · 2023Article
- Design, Synthesis, and Evaluation of Novel ΔJournal of medicinal chemistry · 2023Article
- Molecular Mechanisms of MmpL3 Function and Inhibition.Microbial drug resistance (Larchmont, N.Y.) · 2023Review
- Article
- Multiplexed transcriptional repression identifies a network of bactericidal interactions between mycobacterial respiratory complexes.iScience · 2022Article
- Failing upwards: Genetics-based strategies to improve antibiotic discovery and efficacy inFrontiers in cellular and infection microbiology · 2022Review
- Advances in Key Drug Target Identification and New Drug Development for Tuberculosis.BioMed research international · 2022Review
- Tandem Ring Opening/Intramolecular [2 + 2] Cycloaddition Reaction for the Synthesis of Cyclobutane Fused Thiazolino-2-Pyridones.The Journal of organic chemistry · 2021Article
- An evolutionary functional genomics approach identifies novel candidate regions involved in isoniazid resistance in Mycobacterium tuberculosis.Communications biology · 2021Article
- AC2P20 selectively killsRSC advances · 2021Article
Corrections and comments
- Commented on by
Authors and funding
23 authors at 3 institutions in 2 countries.
Kelly FlentieDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Gregory A HarrisonDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-6050-1312
Hasan TükenmezDepartment of Molecular Biology, Umeå University, SE-90187 Umeå, Sweden.ORCID 0000-0002-2259-6883
Jonathan LivnyInfectious Disease and Microbiome Program, Broad Institute, Cambridge, MA 02142.
James A D GoodUmeå Centre for Microbial Research, Umeå University, SE-90187 Umeå, Sweden.
Souvik SarkarUmeå Centre for Microbial Research, Umeå University, SE-90187 Umeå, Sweden.
Dennis X ZhuDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0001-6159-1607
Rachel L KinsellaDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Leslie A WeissDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Samantha D SolomonDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Miranda E ScheneDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Mette R HansenUmeå Centre for Microbial Research, Umeå University, SE-90187 Umeå, Sweden.
Andrew G CairnsUmeå Centre for Microbial Research, Umeå University, SE-90187 Umeå, Sweden.
Martina KulénUmeå Centre for Microbial Research, Umeå University, SE-90187 Umeå, Sweden.
Torbjörn WixeUmeå Centre for Microbial Research, Umeå University, SE-90187 Umeå, Sweden.
Anders E G LindgrenUmeå Centre for Microbial Research, Umeå University, SE-90187 Umeå, Sweden.
Erik ChorellDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Christoffer BengtssonUmeå Centre for Microbial Research, Umeå University, SE-90187 Umeå, Sweden.
K Syam KrishnanUmeå Centre for Microbial Research, Umeå University, SE-90187 Umeå, Sweden.
Scott J HultgrenDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0001-8785-564X
Christer LarssonDepartment of Molecular Biology, Umeå University, SE-90187 Umeå, Sweden.
Fredrik AlmqvistUmeå Centre for Microbial Research, Umeå University, SE-90187 Umeå, Sweden; fredrik.almqvist@umu.se stallings@wustl.edu.ORCID 0000-0002-0504-4446
Christina L StallingsDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110; fredrik.almqvist@umu.se stallings@wustl.edu.
Umeå University · SEWashington University in St. Louis · USBroad Institute · US
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0MWU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MViral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI CUOMO, CHRISTINA A · 2014 to 2024
$66.5MWashington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MTRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM007067 · NIGMS · WASHINGTON UNIVERSITY · PI TRUE-KROB, HEATHER L · 1985 to 2020
$20.4MChemical disarming of drug resistance in Mycobacterium tuberculosisR01AI134847 · NIAID · WASHINGTON UNIVERSITY · PI ALMQVIST, FREDRIK, STALLINGS, CHRISTINA LEIGH · 2018 to 2021
$2.7MTargeting a New Essential Virulence Mechanism in Drug-Resistant MycobacteriaR33AI111696 · NIAID · WASHINGTON UNIVERSITY · PI STALLINGS, CHRISTINA LEIGH · 2016 to 2018
$1.4MNCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NIAID NIH HHS R01 AI134847NIAID NIH HHS R33 AI111696NIAID NIH HHS U19 AI110818NIGMS NIH HHS T32 GM007067
Abstract
PubMed holds no abstract for this paper.
Indexed as
IsoniazidAntitubercular AgentsDrug Evaluation, PreclinicalDrug Resistance, BacterialMycobacterium tuberculosisAntitubercular AgentsIsoniazidantibiotic resistancedrug toleranceisoniazidMycobacterium tuberculosisrespiration
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.