Evidence map›Paper›PMID 31061099›Full record

ArticleThe Journal of biological chemistry2019

Revising the structure of a new eicosanoid from human platelets to 8,9-11,12-diepoxy-13-hydroxyeicosadienoic acid.

Andrei Kornilov, Paul D Kennedy, Maceler Aldrovandi, Andrew J A Watson, Christine Hinz, Bryan Harless, Joseph Colombo, Kirk M Maxey, Victoria J Tyrrell, Matthew Simon and 5 more

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Andrei KornilovFrom Cayman Chemical, Ann Arbor, Michigan 48108, akornilov@caymanchem.com.
Paul D KennedyFrom Cayman Chemical, Ann Arbor, Michigan 48108.
Maceler AldrovandiSystems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.
Andrew J A WatsonSystems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.
Christine HinzSystems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.
Bryan HarlessFrom Cayman Chemical, Ann Arbor, Michigan 48108.
Joseph ColomboFrom Cayman Chemical, Ann Arbor, Michigan 48108.
Kirk M MaxeyFrom Cayman Chemical, Ann Arbor, Michigan 48108.
Victoria J TyrrellSystems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.
Matthew SimonFrom Cayman Chemical, Ann Arbor, Michigan 48108.
Varinder K AggarwalSchool of Chemistry, University of Bristol, Bristol BS6 6RU, United Kingdom.
William E BoeglinDepartment of Pharmacology and the Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and.
Alan R BrashDepartment of Pharmacology and the Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and.
Robert C MurphyDepartment of Pharmacology, University of Colorado, Aurora, Colorado 80045.ORCID 0000-0002-9430-6515
Valerie B O'DonnellSystems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom, o-donnellvb@cardiff.ac.uk.ORCID 0000-0003-4089-8460

Funding

British Heart Foundation RG/12/11/29815Wellcome Trust 094143/Z/10/ZWellcome Trust 203014/Z/16/Z
6 · The paper itself

Abstract

Eicosanoids are critical mediators of fever, pain, and inflammation generated by immune and tissue cells. We recently described a new bioactive eicosanoid generated by cyclooxygenase-1 (COX-1) turnover during platelet activation that can stimulate human neutrophil integrin expression. On the basis of mass spectrometry (MS/MS and MS

Indexed as

Blood PlateletsChromatography, High Pressure LiquidCyclooxygenase 1EicosanoidsGas Chromatography-Mass SpectrometryHumansHydroxyeicosatetraenoic AcidsIsomerismMagnetic Resonance SpectroscopyMolecular ConformationTandem Mass SpectrometryCyclooxygenase 1EicosanoidsHydroxyeicosatetraenoic Acids8,9–11,12-diepoxy-13-hydroxyeicosadienoic acid (8,9–11,12-DiEp-13-HEDE)8-hydroxy-9,11-dioxolane eicosatetraenoic acid (DXA3)cyclooxygenase (COX)DiEpHEDEeicosanoidimmunityleukocyte-regulating lipidlipidlipid metabolismplatelet

Identifiers

PMID31061099
PMCPMC6556573

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.