Evidence map›Paper›PMID 31061098›Full record

ArticleThe Journal of biological chemistry2019

Sustained sensing in potassium homeostasis: Cyclic di-AMP controls potassium uptake by KimA at the levels of expression and activity.

Jan Gundlach, Larissa Krüger, Christina Herzberg, Asan Turdiev, Anja Poehlein, Igor Tascón, Martin Weiss, Dietrich Hertel, Rolf Daniel, Inga Hänelt and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 89 citations in OpenAlex.

  1. Article
  2. Review
  3. TrkA ofMicrobiology (Reading, England) · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Bacterial cell volume regulation and the importance of cyclic di-AMP.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  11. Regulatory RNAs inSynthetic and systems biotechnology · 2024
    Review
  12. Article
  13. Article
  14. c-di-AMP determines the hierarchical organization of bacterial RCK proteins.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Article
  16. Review
  17. Control of asparagine homeostasis inJournal of bacteriology · 2024
    Article
  18. Article
  19. Cyclic di-AMP traps proton-coupled KNature communications · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 4 countries.

Jan GundlachFrom the Departments of General Microbiology and.
Larissa KrügerFrom the Departments of General Microbiology and.
Christina HerzbergFrom the Departments of General Microbiology and.
Asan Turdievthe Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, and.
Anja PoehleinGenomic and Applied Microbiology, Göttingen Center for Molecular Biosciences, Georg-August-University Göttingen, 37077 Göttingen, Germany, and.
Igor Tascónthe Institute of Biochemistry, Goethe University Frankfurt, 60323 Frankfurt, Germany.ORCID 0000-0003-2526-6238
Martin WeissFrom the Departments of General Microbiology and.ORCID 0000-0002-2596-1938
Dietrich Hertelthe Department of Plant Ecology and Ecosystems Research, Georg-August-University Göttingen, 37077 Göttingen, Germany.
Rolf DanielGenomic and Applied Microbiology, Göttingen Center for Molecular Biosciences, Georg-August-University Göttingen, 37077 Göttingen, Germany, and.ORCID 0000-0002-8646-7925
Inga Häneltthe Institute of Biochemistry, Goethe University Frankfurt, 60323 Frankfurt, Germany.ORCID 0000-0003-1495-3163
Vincent T Leethe Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, and.
Jörg StülkeFrom the Departments of General Microbiology and jstuelk@gwdg.de.ORCID 0000-0001-5881-5390
General Department of Preventive Medicine · VNUniversity of Göttingen · DEGoethe University Frankfurt · DEUniversity of Maryland, College Park · US

Funding

Molecular mechanisms of the stringent response in Mycobacterium tuberculosisR21AI133670 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI BRIKEN, VOLKER, LEE, VINCENT T · 2017 to 2018
$410k
NIAID NIH HHS R21 AI133670
6 · The paper itself

Abstract

The signaling nucleotide cyclic di-AMP (c-di-AMP) is the only known essential second messenger in bacteria. Recently, c-di-AMP has been identified as being essential for controlling potassium uptake in the model organism

Indexed as

HomeostasisBacillus subtilisBacterial ProteinsDinucleoside PhosphatesMutationPotassiumSecond Messenger SystemsBacterial Proteinscyclic diadenosine phosphateDinucleoside PhosphatesPotassiumBacillusBacillus subtilisbacterial geneticscation homeostasiscyclic diadenosine monophosphate (c-di-AMP)cyclic di-AMPdinucleotide signalingosmoregulationpotassium transportprokaryotic signal-transductionsecond messenger

Identifiers

PMID31061098
PMCPMC6579464
OpenAlexW2944793553

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.