ArticleBMJ open2019
Cohort profile: the Trivandrum non-alcoholic fatty liver disease (NAFLD) cohort.
Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
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- Management of metabolic dysfunction-associated steatotic liver disease (MASLD)-An expert consensus statement from Indian diabetologists' perspective.Diabetes, obesity & metabolism · 2025Review
- Rational design of FXR agonists: a computational approach for NASH therapy.Molecular diversity · 2024Article
- Distribution of Normative Percentiles of Liver Stiffness Measurement Using Ultrasound Shear Wave Elastography in an Adult Asian Indian Population.The Indian journal of radiology & imaging · 2024Article
- Steatosis, inflammation, fibroprogression, and cirrhosis in remnant liver post-liver donation.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Editorial: The tip of the non-alcoholic fatty liver disease iceberg-the more we know, the smaller it gets?JGH open : an open access journal of gastroenterology and hepatology · 2023Article
- Identification and characterisation of a rareJHEP reports : innovation in hepatology · 2023Article
- The burgeoning cardiovascular disease epidemic in Indians - perspectives on contextual factors and potential solutions.The Lancet regional health. Southeast Asia · 2023Review
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- Race and Ethnicity in Non-Alcoholic Fatty Liver Disease (NAFLD): A Narrative Review.Nutrients · 2022Review
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- Incorporating neglected non-communicable diseases into the national health program-A review.Frontiers in public health · 2022Review
- Rural-Urban differentials in prevalence, spectrum and determinants of Non-alcoholic Fatty Liver Disease in North Indian population.PloS one · 2022Article
- Nonalcoholic Fatty Liver Disease: Indian Perspective.Clinical liver disease · 2021Review
- Non-alcoholic Fatty Liver Disease: Growing Burden, Adverse Outcomes and Associations.Journal of clinical and translational hepatology · 2020Review
- FibroScan-AST (FAST) Score for Nonalcoholic Steatohepatitis - Validation in an Indian Cohort.Journal of clinical and experimental hepatologyArticle
- "Nonalcoholic Steatohepatitis: A Rapidly Increasing Indication for Liver Transplantation in India".Journal of clinical and experimental hepatologyArticle
- Prevalence of Non-alcoholic Fatty Liver Disease in India: A Systematic Review and Meta-analysis.Journal of clinical and experimental hepatologyArticle
- Indian National Association for Study of the Liver (INASL) Guidance Paper on Nomenclature, Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease (NAFLD).Journal of clinical and experimental hepatologyReview
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe Trivandrum non-alcoholic fatty liver disease (NAFLD) cohort is a population-based study designed to examine the interaction between genetic and lifestyle factors and their association with increased risk of NAFLD within the Indian population.
participantsBetween 2013 and 2016, a total of 2222 participants were recruited to this cohort through multistage cluster sampling across the whole population of Trivandrum-a district within the state of Kerala, South India. Data were collected from all inhabitants of randomly selected households over the age of 25. FINDINGS TO DATE: Full baseline clinical and pathological data were collected from 2158 participants. This included detailed demographic profiles, anthropometric measures and lifestyle data (food frequency, physical activity and anxiety and depression questionnaires). Biochemical profile and ultrasound assessment of the liver were performed and whole blood aliquots were collected for DNA analysis.The NAFLD prevalence within this population was 49.8% which is significantly higher than the global pooled prevalence of 25%. This highlights the importance of robust, prospective studies like this to enable collection of longitudinal data on risk factors, disease progression and to facilitate future interventional studies. FUTURE PLANS: The complete analysis of data collected from this cohort will give valuable insights into the interaction of the phenotypic and genotypic profiles that result in such a dramatic increased risk of NAFLD within the Indian population. The cohort will also form the basis of future lifestyle interventional studies, aimed at improving liver and metabolic health.
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Registered trials
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