Evidence map›Paper›PMID 31061035›Full record

Observational studyBMJ open2019

Does binge drinking between the age of 18 and 25 years predict alcohol dependence in adulthood? A retrospective case-control study in France.

Marie-Pierre Tavolacci, Quentin Berthon, Damiano Cerasuolo, Pierre Dechelotte, Joel Ladner, Alexandre Baguet

Registry-linked trialOpen access · goldAbstract readObservational Study
In one paragraph

Observational study in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03204214 (Binge Drinking And Addiction), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03204214 unknown statusnot on this map

Binge Drinking And Addiction : Case-Control Study in Hospital

TypeobservationalSponsorMarie-Pierre TAVOLACCIRan2016 to 2018Enrolled252ConditionsAlcohol Dependence
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Sex differences in neural circuits driving binge-like drinking: a female-specific role for an amygdalo-striatal pathway.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  6. Review
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  8. How Secondary Interventions Reduce the Burden of Alcohol Consumption at Risk of Cirrhosis: A Public Health Decision-Making Model.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  9. Article
  10. Article
  11. Observational
  12. Cocaine and amphetamine regulated transcript (CART) mediates sex differences in binge drinking through central taste circuits.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  13. Article
  14. Hemichannels contribute to mitochondrial CaFrontiers in cell and developmental biology · 2024
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Marie-Pierre TavolacciCIC 1404 and INSERM 1073, Rouen University Hospital and Rouen Normandy University, Rouen, France.ORCID 0000-0003-3980-819X
Quentin BerthonDepartment of Addictology, Rouen University Hospital, Rouen, France.
Damiano CerasuoloClinical Investigation Center 1404, Rouen University Hospital, Rouen, France.
Pierre DechelotteDepartment of Nutrition and INSERM 1073, Rouen University Hospital and Rouen Normandy University, Rouen, France.
Joel LadnerDepartment of Epidemiology and Health Promotion and INSERM 1073, Rouen University Hospital and Rouen Normandy University, Rouen, France.
Alexandre BaguetDepartment of Addictology and INSERM 1073, Rouen University Hospital and Rouen Normandy University, Rouen, France.
Inserm · FRCentre Hospitalier Universitaire de Rouen · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveA retrospective case-control study was conducted to evaluate whether frequent binge drinking between the age of 18 and 25 years was a risk factor for alcohol dependence in adulthood.

settingThe Department of Addictive Medicine and the Clinical Investigation Center of a university hospital in France.

participantsCases were alcohol-dependent patients between 25 and 45 years and diagnosed by a psychiatrist. Consecutive patients referred to the Department of Addictive Medicine of a university hospital between 1 January 2017 and 31 December 2017 for alcohol dependence were included in the study. Controls were non-alcohol-dependent adults, defined according to an Alcohol Use Disorders Identification Test score of less than 8, and were matched on age and sex with cases. Data on sociodemographics, behaviour and alcohol consumption were retrospectively collected for three life periods: before the age of 18 years; between the age of 18 and 25 years; and between the age of 25 and 45 years. Frequency of binge drinking between 18 and 25 years was categorised as frequent if more than twice a month, occasional if once a month and never if no binge drinking.

results166 adults between 25 and 45 years were included: 83 were alcohol-dependent and 83 were non-alcohol-dependent. The mean age was 34.6 years (SD: 5.1). Frequent binge drinking between 18 and 25 years occurred in 75.9% of cases and 41.0% of controls (p<0.0001). After multivariate analysis, frequent binge drinking between 18 and 25 years was a risk factor for alcohol dependence between 25 and 45 years: adjusted OR=2.83, 95% CI 1.10 to 7.25.

conclusionsFrequent binge drinking between 18 and 25 years appears to be a risk factor for alcohol dependence in adulthood. Prevention measures for binge drinking during preadulthood, especially frequent binge drinking, should be implemented to prevent acute consequences as injury and death and long-term consequences as alcohol dependence. TRIAL REGISTRATION NUMBER: NCT03204214; Results.

Indexed as

AdolescentAdolescent BehaviorAdultAlcoholismBinge DrinkingCase-Control StudiesFemaleFranceHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisRisk FactorsRisk-TakingSex Factorsepidemiologymental healthpublic healthsubstance misuse

Identifiers

PMID31061035
PMCPMC6501952
OpenAlexW2943669274

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.