ArticleThe Journal of pediatrics2019
Childhood Metabolic Biomarkers Are Associated with Performance on Cognitive Tasks in Young Children.
Article in The Journal of pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- A brief bout of moderate intensity physical activity improves preadolescent children's behavioral inhibition but does not change their energy intake.Journal of behavioral medicine · 2024Trial
- Changes in Learning Outcomes after Dietary Intervention in Preschoolers: A Pilot Study.Nutrients · 2021Trial
- Diet, lifestyle, metabolic markers, and socioeconomic status are associated with cognitive function in school-aged children from a population-based cohort.Pediatric research · 2026Article
- Associations Between Nutritional Status, Cognitive Performance, and Surrogate Metabolic Profiles in School-Aged Children.Nutrients · 2026Article
- Brain insulin receptor gene network shapes risk for metabolic disease after early-life stress in women.Communications biology · 2025Article
- Executive functioning difficulties in relation to food addiction, disordered eating attitudes, and metabolic syndrome markers among adolescents seeking obesity treatment: a cross-sectional analysis.Journal of eating disorders · 2025Article
- Children's executive functioning and health behaviors across pediatric life stages and ecological contexts.Journal of behavioral medicine · 2025Article
- Reviewing the Impact of Maternal Opioid Use Disorder on Fetal Development and Long-Term Pediatric Health Outcomes.Cureus · 2024Review
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- Article
- Parental and child genetic burden of glycaemic dysregulation and early-life cognitive development: an Asian and European prospective cohort study.Translational psychiatry · 2024Article
- Neuropsychology and Electroencephalography in Rural Children at Neurodevelopmental Risk: A Scoping Review.Pediatric reports · 2023Article
- Paediatric obesity and metabolic syndrome associations with cognition and the brain in youth: Current evidence and future directions.Pediatric obesity · 2023Review
- Cross-sectional investigation of insulin resistance in youths with autism spectrum disorder. Any role for reduced brain glucose metabolism?Translational psychiatry · 2021Article
- Executive function phenotypes in pediatric obesity.Pediatric obesity · 2020Article
- "Food" and "non-food" self-regulation in childhood: a review and reciprocal analysis.The international journal of behavioral nutrition and physical activity · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveTo evaluate the hypothesis that metabolic measures (fasting glucose, insulin, and Homeostatic Model of Assessment for Insulin Resistance [HOMA-IR] levels) are inversely associated with performance on cognitive tasks using data from young (4- to 6-year-old), typically developing, healthy children. STUDY
designData were obtained from children participating in the Healthy Start study, a pre-birth cohort in Colorado. HOMA-IR, glucose, and insulin values were centered and scaled using the study sample means and SD. Thus, they are reported in number of SD units from the mean. Fully corrected T scores for inhibitory control (Flanker task), cognitive flexibility (Dimensional Change Card Sort test), and receptive language (Picture Vocabulary test) were obtained via the National Institutes of Health Toolbox cognition battery.
resultsChildren included in this analysis (n = 137) were 4.6 years old, on average. Per 1-SD unit, fasting glucose (B = -2.0, 95% CI -3.5, -0.5), insulin (B = -1.7, 95% CI -3.0, -0.4), and HOMA-IR values (B = -1.8, 95% CI -3.1, -0.5) were each significantly and inversely associated with inhibitory control (P < .05 for all, respectively). Fasting glucose levels were also inversely associated with cognitive flexibility (B = -2.0, 95% CI -3.7, -0.2, P = .03).
conclusionsOur data suggest that metabolic health may impact fluid cognitive function in healthy, young children.
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Registered trials
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