Evidence map›Paper›PMID 31060609›Full record

ArticleClinical epigenetics2019

Methylation at cg05575921 of a smoking-related gene (AHRR) in non-smoking Taiwanese adults residing in areas with different PM

Disline Manli Tantoh, Kuan-Jung Lee, Oswald Ndi Nfor, Yi-Chia Liaw, Chin Lin, Hou-Wei Chu, Pei-Hsin Chen, Shu-Yi Hsu, Wen-Hsiu Liu, Chen-Chang Ho and 5 more

Open access · goldAbstract read
In one paragraph

Article in Clinical epigenetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Particulate matter-induced epigenetic modifications and lung complications.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
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  20. Hypomethylation ofGenes · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Disline Manli TantohDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, Taichung City, 40201, Taiwan.
Kuan-Jung LeeDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, Taichung City, 40201, Taiwan.
Oswald Ndi NforDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, Taichung City, 40201, Taiwan.
Yi-Chia LiawDepartment of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan.
Chin LinGraduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.
Hou-Wei ChuInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Pei-Hsin ChenDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, Taichung City, 40201, Taiwan.
Shu-Yi HsuDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, Taichung City, 40201, Taiwan.
Wen-Hsiu LiuDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, Taichung City, 40201, Taiwan.
Chen-Chang HoDepartment of Physical Education, Fu-Jen Catholic University, New Taipei City, Taiwan.
Chia-Chi LungDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, Taichung City, 40201, Taiwan.
Ming-Fang WuDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, Taichung City, 40201, Taiwan.
Yi-Ching LiawInstitute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
Tonmoy DebnathDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, Taichung City, 40201, Taiwan.
Yung-Po LiawDepartment of Public Health and Institute of Public Health, Chung Shan Medical University, No. 110 Sec. 1 Jianguo N. Road, Taichung City, 40201, Taiwan. Liawyp@csmu.edu.tw.
Chung Shan Medical University · TWNational Yang Ming University Hospital · TWFu Jen Catholic University · TWInstitute of Biomedical Sciences, Academia Sinica · TWNational Defense Medical Center · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDNA methylation is associated with cancer, metabolic, neurological, and autoimmune disorders. Hypomethylation of aryl hydrocarbon receptor repressor (AHRR) especially at cg05575921 is associated with smoking and lung cancer. Studies on the association between AHRR methylation at cg05575921 and sources of polycyclic aromatic hydrocarbon (PAH) other than smoking are limited. The aim of our study was to assess the pattern of blood DNA methylation at cg05575921 in non-smoking Taiwanese adults living in areas with different PM

methodsData on blood DNA methylation, smoking, and residence were retrieved from the Taiwan Biobank dataset (2008-2015). Current and former smokers, as well as individuals with incomplete information were excluded from the current study. The final analysis included 708 participants (279 men and 429 women) aged 30-70 years. PM

resultsLiving in PM

conclusionLiving in PM

Indexed as

DNA MethylationNon-SmokersAdultAgedBasic Helix-Loop-Helix ProteinsEpigenesis, GeneticFemaleHumansLung NeoplasmsMaleMiddle AgedParticulate MatterRegression AnalysisRepressor ProteinsTaiwanAHRR protein, humanBasic Helix-Loop-Helix ProteinsParticulate MatterRepressor ProteinsAHRRair pollutionepigeneticsnon-smokingresidential areaTaiwan Biobank

Identifiers

PMID31060609
PMCPMC6503351
OpenAlexW2947997457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.