Evidence map›Paper›PMID 31060353›Full record

ArticleJournal of the American Chemical Society2019

Regio- and Diastereoselective Iron-Catalyzed [4+4]-Cycloaddition of 1,3-Dienes.

C Rose Kennedy, Hongyu Zhong, Rachel L Macaulay, Paul J Chirik

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Review
  3. Alkali-Metal Base Catalyzed Electrocyclization of Isoprene Derivatives.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  4. Multi-layered metabolic remodeling ofMetabolic engineering communications · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Dienes as Versatile Substrates for Transition Metal-Catalyzed Reactions.Angewandte Chemie (International ed. in English) · 2024
    Review
  11. Review
  12. JACS Au · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Catalytic Synthesis of 8-Membered Ring Compounds via Cobalt(III)-Carbene Radicals.Angewandte Chemie (International ed. in English) · 2020
    Article
  19. On the Use of Iron in Organic Chemistry.Molecules (Basel, Switzerland) · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

C Rose KennedyDepartment of Chemistry , Princeton University , Princeton , New Jersey 08544 , United States.ORCID 0000-0003-3681-819X
Hongyu ZhongDepartment of Chemistry , Princeton University , Princeton , New Jersey 08544 , United States.ORCID 0000-0002-6892-482X
Rachel L MacaulayDepartment of Chemistry , Princeton University , Princeton , New Jersey 08544 , United States.ORCID 0000-0002-7110-8110
Paul J ChirikDepartment of Chemistry , Princeton University , Princeton , New Jersey 08544 , United States.ORCID 0000-0001-8473-2898

Funding

A Unified Strategy for Regio- and Stereoselective, Iron-Catalyzed Cycloaddition Reactions of Unactivated OlefinsF32GM126640 · NIGMS · PRINCETON UNIVERSITY · PI KENNEDY, ROSE · 2017 to 2019
$118k
NIGMS NIH HHS F32 GM126640
6 · The paper itself

Abstract

A family of single-component iron precatalysts for the [4+4]-cyclodimerization and intermolecular cross-[4+4]-cycloaddition of monosubstituted 1,3-dienes is described. Cyclooctadiene products were obtained with high regioselectivity, and catalyst-controlled access to either cis- or trans-diastereomers was achieved using 4-substituted diene substrates. Reactions conducted either with single-component precatalysts or with iron dihalide complexes activated in situ proved compatible with common organic functional groups and were applied on multigram scale (up to >100 g). Catalytically relevant, S = 1 iron complexes bearing 2-(imino)pyridine ligands, (

Indexed as

AlkadienesCatalysisCycloaddition ReactionDensity Functional TheoryIronMolecular StructureStereoisomerismAlkadienesIron

Identifiers

PMID31060353
PMCPMC6541524

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.