Evidence map›Paper›PMID 31060342›Full record

ArticleInternational journal of molecular sciences2019

Molecular Signature of Prospero Homeobox 1 (PROX1) in Follicular Thyroid Carcinoma Cells.

Magdalena Rudzińska, Małgorzata Grzanka, Anna Stachurska, Michał Mikula, Katarzyna Paczkowska, Tomasz Stępień, Agnieszka Paziewska, Jerzy Ostrowski, Barbara Czarnocka

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Extracellular Vesicles as Signal Carriers in Malignant Thyroid Tumors?International journal of molecular sciences · 2022
    Article
  5. Article
  6. Long Non-CodingNon-coding RNA · 2021
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Magdalena RudzińskaDepartment of Biochemistry and Molecular Biology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland. magdda.rudzinska@gmail.com.
Małgorzata GrzankaDepartment of Biochemistry and Molecular Biology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland. mgrzanka@cmkp.edu.pl.
Anna StachurskaDepartment of Immunohematology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland. astachurska@cmkp.edu.pl.
Michał MikulaDepartment of Genetics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, 02-781 Warsaw, Poland. mikula.michal@gmail.com.
Katarzyna PaczkowskaDepartment of Genetics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, 02-781 Warsaw, Poland. paczkowska.km@gmail.com.
Tomasz StępieńClinic of Endocrinological and General Surgery, Medical University of Lodz, 93-513 Lodz, Poland. tomsamaz@wp.pl.
Agnieszka PaziewskaDepartment of Gastroenterology, Hepatology and Clinical Oncology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland. apaziewska@cmkp.edu.pl.
Jerzy OstrowskiDepartment of Genetics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, 02-781 Warsaw, Poland. jostrow@warman.com.pl.
Barbara CzarnockaDepartment of Biochemistry and Molecular Biology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland. bczarnocka@cmkp.edu.pl.
Postgraduate School of Molecular Medicine · PLThe Maria Sklodowska-Curie National Research Institute of Oncology · PLMedical University of Lodz · PL

Funding

The National Science Center, Poland 2013/11/N/NZ5/03394 (to M.R.) and 2012/07/B/ NZ5/02444 (to B.C.)
6 · The paper itself

Abstract

The prospero homeobox 1 (PROX1) transcription factor is a product of one of the lymphangiogenesis master genes. It has also been suggested to play a role in carcinogenesis, although its precise role in tumour development and metastasis remains unclear. The aim of this study was to gain more knowledge on the PROX1 function in thyroid tumorigenesis. Follicular thyroid cancer-derived cells-CGTH-W-1-were transfected with PROX1-siRNA (small interfering RNA) and their proliferation, cell cycle, apoptosis and motility were then analysed. The transcriptional signature of

Indexed as

Adenocarcinoma, FollicularApoptosisBiomarkers, TumorBiopsyCell CycleCell Line, TumorCell MovementCell SurvivalGene Expression ProfilingGene Expression Regulation, NeoplasticGene Knockdown TechniquesHigh-Throughput Nucleotide SequencingHomeodomain ProteinsHumansImmunohistochemistryProspero-Related Homeobox 1 ProteinBiomarkers, TumorHomeodomain ProteinsProspero-Related Homeobox 1 ProteinRNA, Small InterferingTumor Suppressor Proteinscytoskeletonfollicular thyroid carcinomainvasionmigrationPROX1RNA-seq

Identifiers

PMID31060342
PMCPMC6539481
OpenAlexW2943609422

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.