ArticleMolecules (Basel, Switzerland)2019
Small Molecule Inhibitors of KDM5 Histone Demethylases Increase the Radiosensitivity of Breast Cancer Cells Overexpressing JARID1B.
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In one paragraph
Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19.The Journal of infectious diseases · 2020Pooled it
- Targeting epigenetic regulators: In-silico discovery of natural inhibitors against histone demethylase KDM4C.PloS one · 2026Article
- A New Look at the Role of Radiation-Related Epigenetic Mechanisms in Diagnosis and Anticancer Therapies.Cells · 2025Review
- Roles of KDM5 demethylases in therapeutic resistance of cancers.Epigenetics & chromatin · 2025Review
- Epigenetics-targeted drugs: current paradigms and future challenges.Signal transduction and targeted therapy · 2024Review
- To Erase or Not to Erase: Non-Canonical Catalytic Functions and Non-Catalytic Functions of Members of Histone Lysine Demethylase Families.International journal of molecular sciences · 2024Review
- KDM5 family as therapeutic targets in breast cancer: Pathogenesis and therapeutic opportunities and challenges.Molecular cancer · 2024Review
- A truncated and catalytically inactive isoform of KDM5B histone demethylase accumulates in breast cancer cells and regulates H3K4 tri-methylation and gene expression.Cancer gene therapy · 2023Article
- H3 Lysine 4 Methylation Is Required for Full Activation of Genes Involved in α-Ketoglutarate Availability in the Nucleus of Yeast Cells after Diauxic Shift.Metabolites · 2023Article
- Wds-Mediated H3K4me3 Modification Regulates Lipid Synthesis and Transport inInternational journal of molecular sciences · 2023Article
- KDM5B expression in cisplatin resistant neuroblastoma cell lines.Oncology letters · 2022Article
- Review
- Male-Specific Activation of Lysine Demethylases 5B and 5C Mediates Alcohol-Induced Liver Injury and Hepatocyte Dedifferentiation.Hepatology communications · 2022Article
- Network Topology of Biological Aging and Geroscience-Guided Approaches to COVID-19.Frontiers in aging · 2021Article
- The molecular basis of mammary gland development and epithelial differentiation.Seminars in cell & developmental biology · 2021Review
- The Role of Histone Lysine Methylation in the Response of Mammalian Cells to Ionizing Radiation.Frontiers in genetics · 2021Review
- Cancer Stem Cells and the Slow Cycling Phenotype: How to Cut the Gordian Knot Driving Resistance to Therapy in Melanoma.Cancers · 2020Article
- JARID1B promotes colorectal cancer proliferation and Wnt/β-catenin signaling via decreasing CDX2 level.Cell communication and signaling : CCS · 2020Article
- ACE2 Expression is Increased in the Lungs of Patients with Comorbidities Associated with Severe COVID-19.medRxiv : the preprint server for health sciences · 2020Article
- Inhibition of Serine Metabolism Promotes Resistance to Cisplatin in Gastric Cancer.OncoTargets and therapy · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 1 country.
Simone PippaDepartment of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, 00185 Rome, Italy. simone.pippa@uniroma1.it.
Cecilia MannironiInstitute of Molecular Biology and Pathology, Italian National Research Council, 00185 Rome, Italy. cecilia.mannironi@uniroma1.it.
Valerio LicursiDepartment of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, 00185 Rome, Italy. valerio.licursi@uniroma1.it.
Luca BombardiDepartment of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, 00185 Rome, Italy. luca.bombardi@uniroma1.it.
Gianni ColottiInstitute of Molecular Biology and Pathology, Italian National Research Council, 00185 Rome, Italy. gianni.colotti@uniroma1.it.
Enrico CundariInstitute of Molecular Biology and Pathology, Italian National Research Council, 00185 Rome, Italy. enrico.cundari@uniroma1.it.
Adriano MollicaDepartment of Pharmacy, University "G. d' Annunzio" of Chieti, Via dei Vestini 31, 66100 Chieti, Italy. adriano.mollica@unich.it.
Antonio ColucciaDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia Cenci Bolognetti Foundation, Sapienza University of Rome, 00185 Rome, Italy. antonio.coluccia@uniroma1.it.ORCID 0000-0002-7940-8206
Valentina NaccaratoDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia Cenci Bolognetti Foundation, Sapienza University of Rome, 00185 Rome, Italy. valentina.naccarato@uniroma1.it.
Giuseppe La ReginaDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia Cenci Bolognetti Foundation, Sapienza University of Rome, 00185 Rome, Italy. giuseppe.laregina@uniroma1.it.ORCID 0000-0003-3252-1161
Romano SilvestriDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia Cenci Bolognetti Foundation, Sapienza University of Rome, 00185 Rome, Italy. romano.silvestri@uniroma1.it.ORCID 0000-0003-2489-0178
Rodolfo NegriDepartment of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, 00185 Rome, Italy. rodolfo.negri@uniroma1.it.
Institute of Molecular Biology and Pathology · ITIstituto Pasteur · ITSapienza University of Rome · ITNational Research Council · ITUniversity of Chieti-Pescara · IT
Funding
Sapienza Università di Roma RM11715C53A3F678
Abstract
PubMed holds no abstract for this paper.
Indexed as
Breast NeoplasmsCell Line, TumorCell ProliferationCell SurvivalFemaleGene Expression Regulation, NeoplasticHistone DemethylasesHistonesHumansJumonji Domain-Containing Histone DemethylasesMCF-7 CellsModels, MolecularMolecular StructureNuclear ProteinsRadiation-Sensitizing AgentsRadiation ToleranceHistone DemethylasesHistonesJumonji Domain-Containing Histone DemethylasesKDM5B protein, humanNuclear ProteinsRadiation-Sensitizing AgentsRepressor ProteinsSmall Molecule Librariesbreast cancerDNA damageepigenetic drugshistone demethylase inhibitors
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.