ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2020
Sleep as a translationally-relevant endpoint in studies of autism spectrum disorder (ASD).
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Reciprocal regulation between autism risk gene POGZ and circadian clock.JCI insight · 2026Article
- Article
- Conserved sleep disturbances in FOXP1 syndrome originate from developmental dysregulation of peptidergic signaling.The Journal of clinical investigation · 2026Article
- Sleep and activity patterns in autism.Autism : the international journal of research and practice · 2026Article
- Analysis of brain functional connectivity in children with autism spectrum disorder and sleep disorders: a fNIRS observational study.Frontiers in psychology · 2025Article
- Circadian desynchrony in early life leads to enduring autistic-like behavioral changes in adulthood.Communications biology · 2024Article
- Effects of chronic sleep restriction on the neuro-phenotypes of Ctnnd2 knockout mice.Brain and behavior · 2023Article
- Early-life sleep disruption impairs subtle social behaviours in prairie voles: a pose-estimation study.Royal Society open science · 2023Article
- The stress of losing sleep: Sex-specific neurobiological outcomes.Neurobiology of stress · 2023Article
- Loss of sleep when it is needed most - Consequences of persistent developmental sleep disruption: A scoping review of rodent models.Neurobiology of sleep and circadian rhythms · 2023Article
- SREBP modulates the NADPNature communications · 2023Article
- Allelic contribution of Nrxn1α to autism-relevant behavioral phenotypes in mice.PLoS genetics · 2023Article
- Identification of atypical sleep microarchitecture biomarkers in children with autism spectrum disorder.Frontiers in psychiatry · 2023Article
- Investigating the contributions of circadian pathway and insomnia risk genes to autism and sleep disturbances.Translational psychiatry · 2022Article
- The trilateral interactions between mammalian target of rapamycin (mTOR) signaling, the circadian clock, and psychiatric disorders: an emerging model.Translational psychiatry · 2022Review
- Early life sleep disruption potentiates lasting sex-specific changes in behavior in genetically vulnerable Shank3 heterozygous autism model mice.Molecular autism · 2022Article
- Article
- Deficiency of autism-related Scn2a gene in mice disrupts sleep patterns and circadian rhythms.Neurobiology of disease · 2022Article
- Thirty Years' History since the Discovery of Pax6: From Central Nervous System Development to Neurodevelopmental Disorders.International journal of molecular sciences · 2022Review
- Synaptic dysfunction connects autism spectrum disorder and sleep disturbances: A perspective from studies in model organisms.Sleep medicine reviews · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Sleep has numerous advantages for aligning clinical and preclinical (basic neuroscience) studies of neuropsychiatric illness. Sleep has high translational relevance, because the same endpoints can be studied in humans and laboratory animals. In addition, sleep experiments are conducive to continuous data collection over long periods (hours/days/weeks) and can be based on highly objective neurophysiological measures. Here, we provide a translationally-oriented review on what is currently known about sleep in the context of autism spectrum disorder (ASD), including ASD-related conditions, thought to have genetic, environmental, or mixed etiologies. In humans, ASD is frequently associated with comorbid medical conditions including sleep disorders. Animal models used in the study of ASD frequently recapitulate dysregulation of sleep and biological (diurnal, circadian) rhythms, suggesting common pathophysiologies across species. As our understanding of the neurobiology of ASD and sleep each become more refined, it is conceivable that sleep-derived metrics may offer more powerful biomarkers of altered neurophysiology in ASD than the behavioral tests currently used in humans or lab animals. As such, the study of sleep in animal models for ASD may enable fundamentally new insights on the condition and represent a basis for strategies that enable the development of more effective therapeutics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.