ArticleBrain, behavior, and immunity2020
Early childhood risk exposures and inflammation in early adolescence.
Article in Brain, behavior, and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed.
- The prospective association between stressful life events and inflammation among adolescents with a history of early institutional rearing.Development and psychopathology · 2020Trial
- Practitioner Review: Infant mental health meets cell and molecular biology - a look to the future.Journal of child psychology and psychiatry, and allied disciplines · 2026Review
- Longitudinal associations between father- and mother-child interactions, coparenting, and child cardiometabolic health.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Age-dependent associations of psychological and family factors on systemic inflammation in childhood acute lymphoblastic leukemia survivors.Journal of cancer survivorship : research and practice · 2026Article
- Child sleep problems mediate prospective associations between fathers' parenting stress and child blood glucose levels.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2025Article
- Psychosocial determinants of oral health outcomes in young children.Frontiers in pediatrics · 2024Article
- Biomarkers of Stress and Inflammation in Children.Biological research for nursing · 2023Article
- The Long Arm of childhood hypothesis and systematic low-grade inflammation: Evidence from parental education of older European adults.SSM - population health · 2023Article
- Early Life Stress, Neuroinflammation, and Psychiatric Illness of Adulthood.Advances in experimental medicine and biology · 2023Review
- Towards a multidimensional model of inflamed depression.Brain, behavior, & immunity - health · 2022Article
- Cytokine alterations in pediatric internalizing disorders: Systematic review and exploratory multi-variate meta-analysis.Brain, behavior, & immunity - health · 2022Article
- Article
- Associations between Adverse Childhood Experiences and the novel inflammatory marker glycoprotein acetyls in two generations of the Avon Longitudinal Study of Parents and Children birth cohort.Brain, behavior, and immunity · 2022Article
- Sex-specific behavioral outcomes of early-life adversity and emerging microglia-dependent mechanisms.Frontiers in behavioral neuroscience · 2022Article
- Early life stress and development: potential mechanisms for adverse outcomes.Journal of neurodevelopmental disorders · 2020Review
- Adverse childhood experiences and early life inflammation in the Avon longitudinal study of parents and children.Psychoneuroendocrinology · 2020Article
- Psychological Stress During Childhood and Adolescence and Its Association With Inflammation Across the Lifespan: A Critical Review and Meta-Analysis.Psychological bulletinArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
There is now reliable evidence that early psychosocial stress exposures are associated with behavioral health in children; the degree to which these same kinds of stress exposures predict physical health outcomes is not yet clear. We investigated the links between economic adversity, family and caregiving stress in early childhood and several markers of immune function in early adolescence. The sample is derived from the Family Life Project, a prospective longitudinal study of at-risk families. Socio-demographic and psychosocial risks have been assessed at regular intervals since the children were first assessed at 2 months of age. When the children were early adolescents, we conducted an in-depth health assessment of a subsample of families; blood samples were collected from venipuncture for interleukin(IL)-6, Tumor Necrosis Factor (TNF)-alpha, and C-reactive protein (CRP), as well as glucocorticoid resistance. Results indicated limited but reliable evidence of an association between early risk exposure and inflammation in adolescence. Specifically, caregiver depressive symptoms in early childhood predicted elevated CRP almost a decade later, and the prediction was significant after accounting for multiple covariates such as socio-economic adversity, health behaviors and body mass index. Our findings provide strong but limited evidence that early stress exposures may be associated with inflammation, suggesting one mechanism linking early stress exposure to compromised behavioral and somatic health.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.