ArticlePLoS biology2019
Feminizer and doublesex knock-outs cause honey bees to switch sexes.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Comprehensive Genome-Wide Analysis of Dmrt Transcription Factors Reveals Their Roles in Sexual Dimorphism inBiology · 2025Article
- Nano colonies: Rearing honey bee queens and their offspring in small laboratory arenas.Heliyon · 2025Article
- In Vitro Comparison of Sex-Specific Splicing Efficiencies ofJournal of developmental biology · 2023Article
- Sexual dimorphism as a facilitator of worker caste evolution in ants.Ecology and evolution · 2023Article
- CRISPR/Cas9-Mediated Mutagenesis of Sex-SpecificCells · 2022Article
- Abundant small RNAs in the reproductive tissues and eggs of the honey bee, Apis mellifera.BMC genomics · 2022Article
- Effects of Functional Depletion ofInsects · 2021Article
- Histopathological Findings in Testes from Apparently Healthy Drones ofVeterinary sciences · 2020Article
- Methylation and gene expression differences between reproductive and sterile bumblebee workers.Evolution letters · 2019Article
- Differentiation of Long Non-Coding RNA and mRNA Expression Profiles in Male and FemaleFrontiers in genetics · 2019Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Honey bees are experts at refuting societal norms. Their matriarchal hives are headed by queens, backed by an all-female workforce, and males die soon after copulation. But the biochemical basis of how these distinct castes and sexes (queens, workers, and drones) arise is poorly understood, partly due to a lack of efficient tools for genetic manipulation. Now, Roth and colleagues have used clustered regularly interspaced short palindromic repeats (CRISPR) to knock out two key genes (feminizer and doublesex) that guide sexual development. Their technique yielded remarkably low rates of genetic mosaicism and offers a promising tool for engineering and phenotyping bees for diverse applications.
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